Metastatic Meningioma Presenting As a Malignant Soft Tissue Tumour

Overview

Journal Clin Sarcoma Res

Publisher Biomed Central

Date 2017 Jan 3

PMID 28042470

Citations 4

Authors

Catherine Mccarthy

Monika Hofer

Marianna Vlychou

Robar Khundkar

Paul Critchley

Simon Cudlip

Olaf Ansorge

Nick A Athanasou

Affiliations

Soon will be listed here.

Abstract

Background: Extracranial metastasis of malignant meningioma to soft tissues is extremely rare and its clinical, radiological and pathological features are not well-characterised.

Case Presentation: We report a case of a 58 year old man who presented with a mobile mass within the left trapezius muscle. The patient had previously undergone surgery for a right frontal lobe high grade anaplastic meningioma. Histology of the soft tissue lesion showed metastatic anaplastic meningioma with clumps of pleomorphic tumour cells which expressed epithelial membrane antigen, cytokeratin and P63 but were negative for other epithelial and mesenchymal markers. A PET-CT scan revealed additional metastatic lesions in the left pleura, liver and iliac bone.

Conclusions: Metastatic malignant meningioma can very rarely present as a high grade pleomorphic malignant soft tissue tumour and needs to be distinguished from soft tissue sarcomas and metastatic carcinomas that express epithelial antigens.

Citing Articles

Metastatic meningioma: a case series and systematic review.

Himic V, Burman R, Fountain D, Hofer M, Livermore L, Jeyaretna D Acta Neurochir (Wien). 2023; 165(10):2873-2883.

PMID: 37491650 PMC: 10542723. DOI: 10.1007/s00701-023-05687-3.

Surgical management of a giant hepatic metastasis from a cranial meningioma 10 years after resection.

Feltracco H, Matar A, Smith S, Blair C, Sarmiento J J Surg Case Rep. 2023; 2023(5):rjad238.

PMID: 37153828 PMC: 10156433. DOI: 10.1093/jscr/rjad238.

Extraaxial Cerebellopontine Angle Medulloblastoma with Multiple Intracranial Metastases in Adult: A Rare Case Report with a Review of Literature.

Singh S, Kumar N Asian J Neurosurg. 2020; 15(3):695-698.

PMID: 33145231 PMC: 7591221. DOI: 10.4103/ajns.AJNS_120_20.

WHO Grade I Meningioma Metastasis to the Lung 26 Years after Initial Surgery: A Case Report and Literature Review.

Enomoto T, Aoki M, Kouzaki Y, Abe H, Imamura N, Iwasaki A NMC Case Rep J. 2019; 6(4):125-129.

PMID: 31592398 PMC: 6776748. DOI: 10.2176/nmccrj.cr.2019-0020.

References

Chuang H, Lee H, Cho D . Intracranial malignant meningioma with multiple spinal metastases--a case report and literature review: case report. Spine (Phila Pa 1976). 2006; 31(26):E1006-10. DOI: 10.1097/01.brs.0000245952.71265.9b. View

Louis D, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee W . The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol. 2016; 131(6):803-20. DOI: 10.1007/s00401-016-1545-1. View

Nguyen N, Chaar B, Osman M . Prevalence and patterns of soft tissue metastasis: detection with true whole-body F-18 FDG PET/CT. BMC Med Imaging. 2007; 7:8. PMC: 2235843. DOI: 10.1186/1471-2342-7-8. View

Surov A, Gottschling S, Mawrin C, Prell J, Spielmann R, Wienke A . Diffusion-Weighted Imaging in Meningioma: Prediction of Tumor Grade and Association with Histopathological Parameters. Transl Oncol. 2015; 8(6):517-23. PMC: 4700293. DOI: 10.1016/j.tranon.2015.11.012. View

Karasick J, Mullan S . A survey of metastatic meningiomas. J Neurosurg. 1974; 40(2):206-12. DOI: 10.3171/jns.1974.40.2.0206. View

Baek B, Shin J, Lee C, Lee J, Lee K . Atypical primary meningioma in the nasal septum with malignant transformation and distant metastasis. BMC Cancer. 2012; 12:275. PMC: 3420263. DOI: 10.1186/1471-2407-12-275. View

Forest F, Berremila S, Gyenes C, Ginguene C, Kassir R, Sulaiman A . Metastatic meningiomas: an unusual clinical and pathological diagnosis with highly variable outcome. J Neurooncol. 2014; 120(2):411-21. DOI: 10.1007/s11060-014-1567-2. View

Enam S, Abdulrauf S, Mehta B, Malik G, Mahmood A . Metastasis in meningioma. Acta Neurochir (Wien). 1996; 138(10):1172-7; discussion 1177-8. DOI: 10.1007/BF01809747. View

Younis G, Sawaya R, Demonte F, Hess K, Albrecht S, Bruner J . Aggressive meningeal tumors: review of a series. J Neurosurg. 1995; 82(1):17-27. DOI: 10.3171/jns.1995.82.1.0017. View

10.

Fabi A, Nuzzo C, Vidiri A, Ciccarese M, Felici A, Cattani F . Bone and lung metastases from intracranial meningioma. Anticancer Res. 2006; 26(5B):3835-7. View

11.

Yuzawa S, Nishihara H, Tanaka S . Genetic landscape of meningioma. Brain Tumor Pathol. 2016; 33(4):237-247. DOI: 10.1007/s10014-016-0271-7. View

12.

Nagar V, Ye J, Ng W, Chan Y, Hui F, Lee C . Diffusion-weighted MR imaging: diagnosing atypical or malignant meningiomas and detecting tumor dedifferentiation. AJNR Am J Neuroradiol. 2008; 29(6):1147-52. PMC: 8118818. DOI: 10.3174/ajnr.A0996. View

13.

Lookingbill D, Spangler N, Sexton F . Skin involvement as the presenting sign of internal carcinoma. A retrospective study of 7316 cancer patients. J Am Acad Dermatol. 1990; 22(1):19-26. DOI: 10.1016/0190-9622(90)70002-y. View

14.

Surov A, Gottschling S, Bolz J, Kornhuber M, Alfieri A, Holzhausen H . Distant metastases in meningioma: an underestimated problem. J Neurooncol. 2013; 112(3):323-7. DOI: 10.1007/s11060-013-1074-x. View

15.

Williamson B, Stanton C, Levine E . Chest wall metastasis from recurrent meningioma. Am Surg. 2001; 67(10):966-8. View

16.

Lee G, Choi S, Kim S, Kwon H . Multiple extracranial metastases of atypical meningiomas. J Korean Neurosurg Soc. 2009; 45(2):107-11. PMC: 2651555. DOI: 10.3340/jkns.2009.45.2.107. View

17.

NEW P, Hesselink J, OCarroll C, Kleinman G . Malignant meningiomas: CT and histologic criteria, including a new CT sign. AJNR Am J Neuroradiol. 1982; 3(3):267-76. PMC: 8331685. View

18.

Spencer P, Helm T . Skin metastases in cancer patients. Cutis. 1987; 39(2):119-21. View

19.

Hakyemez B, Yildirim N, Gokalp G, Erdogan C, Parlak M . The contribution of diffusion-weighted MR imaging to distinguishing typical from atypical meningiomas. Neuroradiology. 2006; 48(8):513-20. DOI: 10.1007/s00234-006-0094-z. View

20.

Cabada T, Bermejo R, Bacaicoa C, Martinez-Penuela A . Metastatic meningioma: The role of whole‑body diffusion-weighted imaging. Oncol Lett. 2012; 2(5):931-933. PMC: 3408014. DOI: 10.3892/ol.2011.329. View