HDAC2 Promotes Loss of Primary Cilia in Pancreatic Ductal Adenocarcinoma

Overview

Journal EMBO Rep

Specialty Molecular Biology

Date 2016 Dec 29

PMID 28028031

Citations 41

Authors

Tetsuo Kobayashi

Kosuke Nakazono

Mio Tokuda

Yu Mashima

Brian David Dynlacht

Hiroshi Itoh

Affiliations

Soon will be listed here.

Abstract

Loss of primary cilia is frequently observed in tumor cells, including pancreatic ductal adenocarcinoma (PDAC) cells, suggesting that the absence of this organelle may promote tumorigenesis through aberrant signal transduction and the inability to exit the cell cycle. However, the molecular mechanisms that explain how PDAC cells lose primary cilia are still ambiguous. In this study, we found that inhibition or silencing of histone deacetylase 2 (HDAC2) restores primary cilia formation in PDAC cells. Inactivation of HDAC2 results in decreased Aurora A expression, which promotes disassembly of primary cilia. We further showed that HDAC2 controls ciliogenesis independently of Kras, which facilitates Aurora A expression. These studies suggest that HDAC2 is a novel regulator of primary cilium formation in PDAC cells.

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