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Susceptibility of Methicillin-resistant Staphylococcus Aureus to the Selenium-containing Compound 2-phenyl-1,2-benzoisoselenazol-3(2H)-one (PZ51)

Overview
Journal Antimicrob Agents Chemother
Publisher American Society for Microbiology
Specialty Pharmacology
Date 1989 Aug 1
PMID 2802564
Citations 16
Authors
R Nozawa
T Yokota
T Fujimoto
Affiliations
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Abstract

The growth of Staphylococcus aureus 209P was inhibited by 0.20 micrograms of 2-phenyl-1,2-benzoisoselenazol-3(2H)-one (PZ51) per ml, while strains of the family Enterobacteriaceae were more resistant to the drug. The MIC for 90% of methicillin-resistant S. aureus strains was 1.56 micrograms/ml, and the drug was bactericidal. The selenium in PZ51 was essential, since its sulfur analog (PZ25) lost the antibacterial activity.

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