Development of a Global Respiratory Severity Score for Respiratory Syncytial Virus Infection in Infants

Overview

Journal J Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2016 Dec 25

PMID 28011907

Citations 25

Authors

Mary T Caserta

Xing Qiu

Brenda Tesini

Lu Wang

Amy Murphy

Anthony Corbett

David J Topham

Ann R Falsey

Jeanne Holden-Wiltse

Edward E Walsh

Affiliations

Soon will be listed here.

Abstract

Background: Respiratory syncytial virus (RSV) infection in infants has recognizable clinical signs and symptoms. However, quantification of disease severity is difficult, and published scores remain problematic. Thus, as part of a RSV pathogenesis study, we developed a global respiratory severity score (GRSS) as a research tool for evaluating infants with primary RSV infection.

Methods: Previously healthy infants <10 months of age with RSV infections representing the spectrum of disease severity were prospectively evaluated. Clinical signs and symptoms were collected at 3 time points from hospitalized infants and those seen in ambulatory settings. Data were also extracted from office, emergency department, and hospital records. An unbiased data-driven approach using factor analysis was used to develop a GRSS.

Results: A total of 139 infants (84 hospitalized and 55 nonhospitalized) were enrolled. Using hospitalization status as the output variable, 9 clinical variables were identified and weighted to produce a composite GRSS. The GRSS had an area under the receiver operator curve of 0.961. Construct validity was demonstrated via a significant correlation with length of stay (r = 0.586, P < .0001).

Conclusions: Using routine clinical variables, we developed a severity score for infants with RSV infection that should be useful as an end point for investigation of disease pathogenesis and as an outcome measure for therapeutic interventions.

Citing Articles

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Comparison of three clinical scoring tools for bronchiolitis to predict the need for respiratory support and length of stay in neonates and infants up to three months of age.

De Rose D, Maddaloni C, Martini L, Braguglia A, Dotta A, Auriti C Front Pediatr. 2023; 11:1040354.

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