Mechanisms of Pluripotency Maintenance in Mouse Embryonic Stem Cells

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2016 Dec 22

PMID 27999898

Citations 14

Authors

Chen-Yun Chen

Yuan-Yuan Cheng

Christopher Y T Yen

Patrick C H Hsieh

Affiliations

Soon will be listed here.

Abstract

Mouse embryonic stem cells (mESCs), characterized by their pluripotency and capacity for self-renewal, are driven by a complex gene expression program composed of several regulatory mechanisms. These mechanisms collaborate to maintain the delicate balance of pluripotency gene expression and their disruption leads to loss of pluripotency. In this review, we provide an extensive overview of the key pillars of mESC pluripotency by elaborating on the various essential transcription factor networks and signaling pathways that directly or indirectly support this state. Furthermore, we consider the latest developments in the role of epigenetic regulation, such as noncoding RNA signaling or histone modifications.

Citing Articles

Mechanisms of Embryonic Stem Cell Pluripotency Maintenance and Their Application in Livestock and Poultry Breeding.

Wang Z, Gong W, Yao Z, Jin K, Niu Y, Li B Animals (Basel). 2024; 14(12).

PMID: 38929361 PMC: 11201147. DOI: 10.3390/ani14121742.

Embryonic Stem Cells Can Generate Oral Epithelia under Matrix Instruction.

Das R, Harper L, Kitajima K, Osman T, Cimpan M, Johannssen A Int J Mol Sci. 2023; 24(9).

PMID: 37175400 PMC: 10177836. DOI: 10.3390/ijms24097694.

FAM122A Is Required for Mesendodermal and Cardiac Differentiation of Embryonic Stem Cells.

Yang Y, Liu M, Yan Z, Chen G, Huang Y Stem Cells. 2023; 41(4):354-367.

PMID: 36715298 PMC: 10498146. DOI: 10.1093/stmcls/sxad008.

METTL3 modulates chromatin and transcription dynamics during cell fate transition.

Liu X, Mao Y, Wang S, Zhou J, Qian S Cell Mol Life Sci. 2022; 79(11):559.

PMID: 36266520 PMC: 11803071. DOI: 10.1007/s00018-022-04590-x.

Trim28 citrullination maintains mouse embryonic stem cell pluripotency via regulating Nanog and Klf4 transcription.

Zhang Y, Wan X, Qiu L, Zhou L, Huang Q, Wei M Sci China Life Sci. 2022; 66(3):545-562.

PMID: 36100837 DOI: 10.1007/s11427-022-2167-3.

References

Peters A, Kubicek S, Mechtler K, OSullivan R, Derijck A, Perez-Burgos L . Partitioning and plasticity of repressive histone methylation states in mammalian chromatin. Mol Cell. 2003; 12(6):1577-89. DOI: 10.1016/s1097-2765(03)00477-5. View

Qin J, Whyte W, Anderssen E, Apostolou E, Chen H, Akbarian S . The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. Cell Stem Cell. 2012; 11(3):319-32. PMC: 3647456. DOI: 10.1016/j.stem.2012.06.002. View

Hamazaki T, Kehoe S, Nakano T, Terada N . The Grb2/Mek pathway represses Nanog in murine embryonic stem cells. Mol Cell Biol. 2006; 26(20):7539-49. PMC: 1636849. DOI: 10.1128/MCB.00508-06. View

Caronna E, Patterson E, Hummert P, Kroll K . Geminin restrains mesendodermal fate acquisition of embryonic stem cells and is associated with antagonism of Wnt signaling and enhanced polycomb-mediated repression. Stem Cells. 2013; 31(8):1477-87. PMC: 3776023. DOI: 10.1002/stem.1410. View

Bourillot P, Savatier P . Krüppel-like transcription factors and control of pluripotency. BMC Biol. 2010; 8:125. PMC: 2946285. DOI: 10.1186/1741-7007-8-125. View

Smith A, Heath J, Donaldson D, Wong G, Moreau J, Stahl M . Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides. Nature. 1988; 336(6200):688-90. DOI: 10.1038/336688a0. View

Jones P, Taylor S . Cellular differentiation, cytidine analogs and DNA methylation. Cell. 1980; 20(1):85-93. DOI: 10.1016/0092-8674(80)90237-8. View

Navarro P, Chambers I, Karwacki-Neisius V, Chureau C, Morey C, Rougeulle C . Molecular coupling of Xist regulation and pluripotency. Science. 2008; 321(5896):1693-5. DOI: 10.1126/science.1160952. View

Stahl N, Farruggella T, Boulton T, Zhong Z, Darnell Jr J, Yancopoulos G . Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science. 1995; 267(5202):1349-53. DOI: 10.1126/science.7871433. View

10.

Sears R, Nuckolls F, Haura E, Taya Y, Tamai K, Nevins J . Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev. 2000; 14(19):2501-14. PMC: 316970. DOI: 10.1101/gad.836800. View

11.

Judson R, Babiarz J, Venere M, Blelloch R . Embryonic stem cell-specific microRNAs promote induced pluripotency. Nat Biotechnol. 2009; 27(5):459-61. PMC: 2743930. DOI: 10.1038/nbt.1535. View

12.

Jiang J, Chan Y, Loh Y, Cai J, Tong G, Lim C . A core Klf circuitry regulates self-renewal of embryonic stem cells. Nat Cell Biol. 2008; 10(3):353-60. DOI: 10.1038/ncb1698. View

13.

Quinn J, Chang H . Unique features of long non-coding RNA biogenesis and function. Nat Rev Genet. 2015; 17(1):47-62. DOI: 10.1038/nrg.2015.10. View

14.

Tsumura A, Hayakawa T, Kumaki Y, Takebayashi S, Sakaue M, Matsuoka C . Maintenance of self-renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b. Genes Cells. 2006; 11(7):805-14. DOI: 10.1111/j.1365-2443.2006.00984.x. View

15.

Avilion A, Nicolis S, Pevny L, Perez L, Vivian N, Lovell-Badge R . Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev. 2003; 17(1):126-40. PMC: 195970. DOI: 10.1101/gad.224503. View

16.

Shi Y, Massague J . Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell. 2003; 113(6):685-700. DOI: 10.1016/s0092-8674(03)00432-x. View

17.

Tavares L, Dimitrova E, Oxley D, Webster J, Poot R, Demmers J . RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3. Cell. 2012; 148(4):664-78. PMC: 3281992. DOI: 10.1016/j.cell.2011.12.029. View

18.

Wang K, Chang H . Molecular mechanisms of long noncoding RNAs. Mol Cell. 2011; 43(6):904-14. PMC: 3199020. DOI: 10.1016/j.molcel.2011.08.018. View

19.

Chen C, Ridzon D, Lee C, Blake J, Sun Y, Strauss W . Defining embryonic stem cell identity using differentiation-related microRNAs and their potential targets. Mamm Genome. 2007; 18(5):316-27. DOI: 10.1007/s00335-007-9032-6. View

20.

Struhl G . A gene product required for correct initiation of segmental determination in Drosophila. Nature. 1981; 293(5827):36-41. DOI: 10.1038/293036a0. View