Exercise and Beta-Glucan Consumption (Saccharomyces Cerevisiae) Improve the Metabolic Profile and Reduce the Atherogenic Index in Type 2 Diabetic Rats (HFD/STZ)

Overview

Journal Nutrients

Date 2016 Dec 22

PMID 27999319

Citations 12

Authors

Eric Francelino Andrade

Andressa Ribeiro Veiga Lima

Ingrid Edwiges Nunes

Debora Ribeiro Orlando

Paula Novato Gondim

Marcio Gilberto Zangeronimo

Fernando Henrique Ferrari Alves

Luciano Jose Pereira

Affiliations

Soon will be listed here.

Abstract

Physical activity and the ingestion of dietary fiber are non-drug alternatives commonly used as adjuvants to glycemic control in diabetic individuals. Among these fibers, we can highlight beta-glucans. However, few studies have compared isolated and synergic effects of physical exercise and beta-glucan ingestion, especially in type 2 diabetic rats. Therefore, we evaluated the effects beta-glucan () consumption, associated or not to exercise, on metabolic parameters of diabetic Wistar rats. The diabetes (DM) was induced by high-fat diet (HFD) associated with a low dose of streptozotocin (STZ-35 mg/kg). Trained groups were submitted to eight weeks of exercise in aquatic environment. In the last 28 days of experiment, animals received 30 mg/kg/day of beta-glucan by gavage. Isolated use of beta-glucan decreased glucose levels in fasting, Glycated hemoglobin (HbA1c), triglycerides (TAG), total cholesterol (TC), low-density lipoprotein (LDL-C), the atherogenic index of plasma. Exercise alone also decreased blood glucose levels, HbA1c, and renal lesions. An additive effect for reducing the atherogenic index of plasma and renal lesions was observed when both treatments were combined. It was concluded that both beta-glucan and exercise improved metabolic parameters in type 2 (HFD/STZ) diabetic rats.

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