Cyclooxygenase-2 in Tumor-associated Macrophages Promotes Metastatic Potential of Breast Cancer Cells Through Akt Pathway

Overview

Journal Int J Biol Sci

Specialty Biology

Date 2016 Dec 21

PMID 27994517

Citations 38

Authors

Lu Gan

Zhu Qiu

Jing Huang

Yunhai Li

Hongyan Huang

Tingxiu Xiang

Jingyuan Wan

Tianli Hui

Yong Lin

Hongzhong Li

Guosheng Ren

Affiliations

Soon will be listed here.

Abstract

Tumor-associated macrophages (TAMs) promote cancer development and progression by releasing various cytokines and chemokines. Previously, we have found that the number of COX-2 TAMs was associated with lymph node metastasis in breast cancer. However, the mechanism remains enigmatic. In this study, we show that COX-2 in breast TAMs enhances the metastatic potential of breast cancer cells. COX-2 in TAMs induces MMP-9 expression and promotes epithelial-mesenchymal transition (EMT) in breast cancer cells. In addition, COX-2/PGE induces IL-6 release in macrophages. Furthermore, we find that the activation of Akt pathway in cancer cells is crucial for the pro-metastatic effect of COX-2 TAMs by regulating MMP-9 and EMT. These findings indicate that TAMs facilitate breast cancer cell metastasis through COX-2-mediated intercellular communication.

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