Epithelial-mesenchymal Transition---A Hallmark of Breast Cancer Metastasis

Overview

Journal Cancer Hallm

Publisher American Scientific Publishers

Date 2014 Mar 11

PMID 24611128

Citations 86

Authors

Yifan Wang

Binhua P Zhou

Affiliations

Soon will be listed here.

Abstract

Epithelial-mesenchymal transition (EMT) is a highly conserved cellular program that converts polarized, immotile epithelial cells to migratory mesenchymal cells. In addition, EMT was initially recognized as a key step for morphogenesis during embryonic development. Emerging evidences indicate that this important developmental program promotes metastasis, drug resistance, and tumor recurrence, features that are associated with a poor clinical outcome for patients with breast cancer. Therefore, better understanding of regulation and signaling pathways in EMT is essential to develop novel targeted therapeutics. In this review, we present updated developments underlying EMT in tumor progression and metastasis, and discuss the challenges remaining in breast cancer research.

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