Matching at Human Leukocyte Antigen-C Improved the Outcomes After Double Umbilical Cord Blood Transplantation for Recipients of Two to Four of Six Human Leukocyte Antigen-Matched Grafts
Overview
Authors
Affiliations
We studied the effect of HLA-C matching in 515 patients after double umbilical cord blood (UCB) transplantation. After HLA matching HLA-A, -B, and -DRB1 at the allele level, we scored patients according to number of donor-recipient HLA-C matches at 4 possible loci: 2 from each donor unit, at the allele level. Given a direct interaction between HLA-A, -B, and -DRB1 matching and HLA-C score, we analyzed HLA-C matching in those receiving at least 1 2/6 to 4/6 HLA-matched unit (n = 389) versus those receiving only 5/6 or 6/6-matched units (n = 126). In those with at least 1 2/6 to 4/6 HLA-matched unit, a better HLA-C matching score was associated with significantly lower risk of death of any cause and nonrelapse mortality and better disease-free survival. There was no association with the risk of relapse, acute and chronic graft-versus-host disease, and hematopoietic recovery. In contrast, among patients receiving only allele-level 5/6 or 6/6 HLA-matched UCB units, HLA-C match had no demonstrable effect on any outcome. For patients receiving at least 1 allele-level 2/6 to 4/6 HLA-matched UCB unit, matching at HLA-C reduces nonrelapse mortality and improves survival.
Role of Stem-Cell Transplantation in Leukemia Treatment.
Dessie G, Molla M, Shibabaw T, Ayelign B Stem Cells Cloning. 2020; 13:67-77.
PMID: 32982314 PMC: 7493021. DOI: 10.2147/SCCAA.S262880.
Composite GRFS and CRFS Outcomes After Adult Alternative Donor HCT.
Mehta R, Holtan S, Wang T, Hemmer M, Spellman S, Arora M J Clin Oncol. 2020; 38(18):2062-2076.
PMID: 32364845 PMC: 7302955. DOI: 10.1200/JCO.19.00396.
Vanegas D, Galindo C, Paez-Gutierrez I, Gonzalez-Acero L, Medina-Valderrama P, Lozano J Int J Mol Sci. 2019; 20(19).
PMID: 31575081 PMC: 6801469. DOI: 10.3390/ijms20194875.
Dehn J, Spellman S, Hurley C, Shaw B, Barker J, Burns L Blood. 2019; 134(12):924-934.
PMID: 31292117 PMC: 6753623. DOI: 10.1182/blood.2019001212.
Martinez-Losada C, Martin C, Gonzalez R, Manzanares B, Garcia-Torres E, Herrera C Front Immunol. 2017; 8:810.
PMID: 28751893 PMC: 5507950. DOI: 10.3389/fimmu.2017.00810.