Versatile Loading of Diverse Cargo into Functional Polymer Capsules

Overview

Journal Adv Sci (Weinh)

Specialty Biomedical Engineering

Date 2016 Dec 17

PMID 27980899

Citations 3

Authors

Joseph J Richardson

James W Maina

Hirotaka Ejima

Ming Hu

Junling Guo

Mei Y Choy

Sylvia T Gunawan

Lien Lybaert

Christoph E Hagemeyer

Bruno G De Geest

Frank Caruso

Affiliations

Soon will be listed here.

Abstract

Polymer microcapsules are of particular interest for applications including self-healing coatings, catalysis, bioreactions, sensing, and drug delivery. The primary way that polymer capsules can exhibit functionality relevant to these diverse fields is through the incorporation of functional cargo in the capsule cavity or wall. Diverse functional and therapeutic cargo can be loaded into polymer capsules with ease using polymer-stabilized calcium carbonate (CaCO) particles. A variety of examples are demonstrated, including 15 types of cargo, yielding a toolbox with effectively 500+ variations. This process uses no harsh reagents and can take less than 30 min to prepare, load, coat, and form the hollow capsules. For these reasons, it is expected that the technique will play a crucial role across scientific studies in numerous fields.

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Versatile Loading of Diverse Cargo into Functional Polymer Capsules.

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PMID: 27980899 PMC: 5115278. DOI: 10.1002/advs.201400007.

References

De Cock L, De Koker S, De Geest B, Grooten J, Vervaet C, Remon J . Polymeric multilayer capsules in drug delivery. Angew Chem Int Ed Engl. 2010; 49(39):6954-73. DOI: 10.1002/anie.200906266. View

Zelikin A, Becker A, Johnston A, Wark K, Turatti F, Caruso F . A general approach for DNA encapsulation in degradable polymer microcapsules. ACS Nano. 2009; 1(1):63-9. DOI: 10.1021/nn700063w. View

Yan Y, Ochs C, Such G, Heath J, Nice E, Caruso F . Bypassing multidrug resistance in cancer cells with biodegradable polymer capsules. Adv Mater. 2010; 22(47):5398-403. DOI: 10.1002/adma.201003162. View

Richardson J, Bjornmalm M, Gunawan S, Guo J, Liang K, Tardy B . Convective polymer assembly for the deposition of nanostructures and polymer thin films on immobilized particles. Nanoscale. 2014; 6(22):13416-20. DOI: 10.1039/c4nr04348k. View

De Koker S, Hoogenboom R, De Geest B . Polymeric multilayer capsules for drug delivery. Chem Soc Rev. 2012; 41(7):2867-84. DOI: 10.1039/c2cs15296g. View

Peyratout C, Dahne L . Tailor-made polyelectrolyte microcapsules: from multilayers to smart containers. Angew Chem Int Ed Engl. 2004; 43(29):3762-83. DOI: 10.1002/anie.200300568. View

Ejima H, Richardson J, Liang K, Best J, van Koeverden M, Such G . One-step assembly of coordination complexes for versatile film and particle engineering. Science. 2013; 341(6142):154-7. DOI: 10.1126/science.1237265. View

Daniel M, Astruc D . Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Chem Rev. 2004; 104(1):293-346. DOI: 10.1021/cr030698+. View

Sukhorukov G, Rogach A, Garstka M, Springer S, Parak W, Munoz-Javier A . Multifunctionalized polymer microcapsules: novel tools for biological and pharmacological applications. Small. 2007; 3(6):944-55. DOI: 10.1002/smll.200600622. View

10.

Kreno L, Leong K, Farha O, Allendorf M, Van Duyne R, Hupp J . Metal-organic framework materials as chemical sensors. Chem Rev. 2011; 112(2):1105-25. DOI: 10.1021/cr200324t. View

11.

Hosta-Rigau L, Shimoni O, Stadler B, Caruso F . Advanced subcompartmentalized microreactors: polymer hydrogel carriers encapsulating polymer capsules and liposomes. Small. 2013; 9(21):3573-83. DOI: 10.1002/smll.201300125. View

12.

Hu M, Furukawa S, Ohtani R, Sukegawa H, Nemoto Y, Reboul J . Synthesis of Prussian blue nanoparticles with a hollow interior by controlled chemical etching. Angew Chem Int Ed Engl. 2011; 51(4):984-8. DOI: 10.1002/anie.201105190. View

13.

Parakhonskiy B, Yashchenok A, Donatan S, Volodkin D, Tessarolo F, Antolini R . Macromolecule loading into spherical, elliptical, star-like and cubic calcium carbonate carriers. Chemphyschem. 2014; 15(13):2817-22. DOI: 10.1002/cphc.201402136. View

14.

Pastorino L, Erokhina S, Caneva-Soumetz F, Ruggiero C . Paclitaxel-containing nano-engineered polymeric capsules towards cancer therapy. J Nanosci Nanotechnol. 2009; 9(11):6753-9. DOI: 10.1166/jnn.2009.1580. View

15.

Rivera-Gil P, De Koker S, De Geest B, Parak W . Intracellular processing of proteins mediated by biodegradable polyelectrolyte capsules. Nano Lett. 2009; 9(12):4398-402. DOI: 10.1021/nl902697j. View

16.

Lee J, Farha O, Roberts J, Scheidt K, Nguyen S, Hupp J . Metal-organic framework materials as catalysts. Chem Soc Rev. 2009; 38(5):1450-9. DOI: 10.1039/b807080f. View

17.

Liu R, Mahurin S, Li C, Unocic R, Idrobo J, Gao H . Dopamine as a carbon source: the controlled synthesis of hollow carbon spheres and yolk-structured carbon nanocomposites. Angew Chem Int Ed Engl. 2011; 50(30):6799-802. DOI: 10.1002/anie.201102070. View

18.

Kobayashi H, Brechbiel M . Dendrimer-based macromolecular MRI contrast agents: characteristics and application. Mol Imaging. 2003; 2(1):1-10. DOI: 10.1162/15353500200303100. View

19.

Volodkin D, Larionova N, Sukhorukov G . Protein encapsulation via porous CaCO3 microparticles templating. Biomacromolecules. 2004; 5(5):1962-72. DOI: 10.1021/bm049669e. View

20.

Du C, Shi J, Shi J, Zhang L, Cao S . PUA/PSS multilayer coated CaCO3 microparticles as smart drug delivery vehicles. Mater Sci Eng C Mater Biol Appl. 2013; 33(7):3745-52. DOI: 10.1016/j.msec.2013.05.004. View