Mimicking Biological Functionality with Polymers for Biomedical Applications

Overview

Journal Nature

Specialty Science

Date 2016 Dec 16

PMID 27974772

Citations 116

Authors

Jordan J Green

Jennifer H Elisseeff

Affiliations

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Abstract

The vast opportunities for biomaterials design and functionality enabled by mimicking nature continue to stretch the limits of imagination. As both biological understanding and engineering capabilities develop, more sophisticated biomedical materials can be synthesized that have multifaceted chemical, biological and physical characteristics designed to achieve specific therapeutic goals. Mimicry is being used in the design of polymers for biomedical applications that are required locally in tissues, systemically throughout the body, and at the interface with tissues.

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References

Park K, Kim P, Grinthal A, He N, Fox D, Weaver J . Condensation on slippery asymmetric bumps. Nature. 2016; 531(7592):78-82. DOI: 10.1038/nature16956. View

Johnson R, Halder G . The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment. Nat Rev Drug Discov. 2013; 13(1):63-79. PMC: 4167640. DOI: 10.1038/nrd4161. View

Sun Y, Aw Yong K, Villa-Diaz L, Zhang X, Chen W, Philson R . Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells. Nat Mater. 2014; 13(6):599-604. PMC: 4051885. DOI: 10.1038/nmat3945. View

Singh A, Corvelli M, Unterman S, Wepasnick K, McDonnell P, Elisseeff J . Enhanced lubrication on tissue and biomaterial surfaces through peptide-mediated binding of hyaluronic acid. Nat Mater. 2014; 13(10):988-95. PMC: 6317357. DOI: 10.1038/nmat4048. View

Lin C, Anseth K . Cell-cell communication mimicry with poly(ethylene glycol) hydrogels for enhancing beta-cell function. Proc Natl Acad Sci U S A. 2011; 108(16):6380-5. PMC: 3080983. DOI: 10.1073/pnas.1014026108. View

Beck J, Singh A, Rothenberg A, Elisseeff J, Ewald A . The independent roles of mechanical, structural and adhesion characteristics of 3D hydrogels on the regulation of cancer invasion and dissemination. Biomaterials. 2013; 34(37):9486-95. PMC: 3832184. DOI: 10.1016/j.biomaterials.2013.08.077. View

Hanson M, Bershteyn A, Crespo M, Irvine D . Antigen delivery by lipid-enveloped PLGA microparticle vaccines mediated by in situ vesicle shedding. Biomacromolecules. 2014; 15(7):2475-81. PMC: 4115588. DOI: 10.1021/bm500337r. View

Kloxin A, Kasko A, Salinas C, Anseth K . Photodegradable hydrogels for dynamic tuning of physical and chemical properties. Science. 2009; 324(5923):59-63. PMC: 2756032. DOI: 10.1126/science.1169494. View

Meyer R, Sunshine J, Perica K, Kosmides A, Aje K, Schneck J . Biodegradable nanoellipsoidal artificial antigen presenting cells for antigen specific T-cell activation. Small. 2015; 11(13):1519-25. PMC: 4529071. DOI: 10.1002/smll.201402369. View

10.

Haring M, Vestergaard G, Rachel R, Chen L, Garrett R, Prangishvili D . Virology: independent virus development outside a host. Nature. 2005; 436(7054):1101-2. DOI: 10.1038/4361101a. View

11.

Ye C, Nikolov S, Calabrese R, Dindar A, Alexeev A, Kippelen B . Self-(Un)rolling Biopolymer Microstructures: Rings, Tubules, and Helical Tubules from the Same Material. Angew Chem Int Ed Engl. 2015; 54(29):8490-3. DOI: 10.1002/anie.201502485. View

12.

Sosale N, Rouhiparkouhi T, Bradshaw A, Dimova R, Lipowsky R, Discher D . Cell rigidity and shape override CD47's "self"-signaling in phagocytosis by hyperactivating myosin-II. Blood. 2014; 125(3):542-52. PMC: 4296014. DOI: 10.1182/blood-2014-06-585299. View

13.

Mahdavi A, Ferreira L, Sundback C, Nichol J, Chan E, Carter D . A biodegradable and biocompatible gecko-inspired tissue adhesive. Proc Natl Acad Sci U S A. 2008; 105(7):2307-12. PMC: 2268132. DOI: 10.1073/pnas.0712117105. View

14.

Lashof-Sullivan M, Shoffstall E, Atkins K, Keane N, Bir C, VandeVord P . Intravenously administered nanoparticles increase survival following blast trauma. Proc Natl Acad Sci U S A. 2014; 111(28):10293-8. PMC: 4104920. DOI: 10.1073/pnas.1406979111. View

15.

Roche E, Fabozzo A, Lee Y, Polygerinos P, Friehs I, Schuster L . A light-reflecting balloon catheter for atraumatic tissue defect repair. Sci Transl Med. 2015; 7(306):306ra149. DOI: 10.1126/scitranslmed.aaa2406. View

16.

Lutolf M, Hubbell J . Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. Nat Biotechnol. 2005; 23(1):47-55. DOI: 10.1038/nbt1055. View

17.

Goldsmith C, Miller S . Modern uses of electron microscopy for detection of viruses. Clin Microbiol Rev. 2009; 22(4):552-63. PMC: 2772359. DOI: 10.1128/CMR.00027-09. View

18.

Perica K, Bieler J, Schutz C, Varela J, Douglass J, Skora A . Enrichment and Expansion with Nanoscale Artificial Antigen Presenting Cells for Adoptive Immunotherapy. ACS Nano. 2015; 9(7):6861-71. PMC: 5082131. DOI: 10.1021/acsnano.5b02829. View

19.

Beachley V, Wolf M, Sadtler K, Manda S, Jacobs H, Blatchley M . Tissue matrix arrays for high-throughput screening and systems analysis of cell function. Nat Methods. 2015; 12(12):1197-204. PMC: 4666781. DOI: 10.1038/nmeth.3619. View

20.

Lee T, Garcia J, Paez J, Singh A, Phelps E, Weis S . Light-triggered in vivo activation of adhesive peptides regulates cell adhesion, inflammation and vascularization of biomaterials. Nat Mater. 2014; 14(3):352-60. PMC: 4336636. DOI: 10.1038/nmat4157. View