Disease Drivers of Aging

Overview

Journal Ann N Y Acad Sci

Specialty Science

Date 2016 Dec 13

PMID 27943360

Citations 66

Authors

Richard J Hodes

Felipe Sierra

Steven N Austad

Elissa Epel

Gretchen N Neigh

Kristine M Erlandson

Marissa J Schafer

Nathan K LeBrasseur

Christopher Wiley

Judith Campisi

Mary E Sehl

Rosario Scalia

Satoru Eguchi

Balakuntalam S Kasinath

Jeffrey B Halter

Harvey Jay Cohen

Wendy Demark-Wahnefried

Tim A Ahles

Nir Barzilai

Arti Hurria

Peter W Hunt

Affiliations

Soon will be listed here.

Abstract

It has long been known that aging, at both the cellular and organismal levels, contributes to the development and progression of the pathology of many chronic diseases. However, much less research has examined the inverse relationship-the contribution of chronic diseases and their treatments to the progression of aging-related phenotypes. Here, we discuss the impact of three chronic diseases (cancer, HIV/AIDS, and diabetes) and their treatments on aging, putative mechanisms by which these effects are mediated, and the open questions and future research directions required to understand the relationships between these diseases and aging.

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