Humoral Immune Response to Influenza Vaccination in Patients with Primary Immunoglobulin A Nephropathy. An Analysis of Isotype Distribution and Size of the Influenza-specific Antibodies

Overview

Journal J Clin Invest

Specialty General Medicine

Date 1989 Oct 1

PMID 2794045

Citations 27

Authors

A W van den Wall Bake

W E Beyer

J Hermans

M R Daha

N Masurel

L A van Es

Affiliations

Soon will be listed here.

Abstract

Primary IgA nephropathy (IgAN) is characterized by mesangial deposits of IgA1, increased serum IgA1 levels, and circulating immune complexes containing predominantly IgA1. It has previously been found that patients with IgAN have a higher than normal IgA response to vaccination, but the IgA subclasses have not been studied. To investigate whether the IgA hyperresponsiveness is limited to the subclass IgA1, which is involved in the pathogenesis of IgAN, we compared the immune responses of 18 patients with 22 healthy controls after intramuscular vaccination with inactivated influenza virus. Antibody titers were significantly higher (P less than 0.0001) for the IgA1 subclass in patients versus controls, but not for the other isotypes. A substantial portion of the IgA and IgA1 antiinfluenza immune response comprised polymers in both patients and controls. There was no preferential response of polymers in patients. Patients produced significantly more monomeric IgA1 antibodies than controls. These results show that patients with IgAN have a hyperresponsiveness limited to the subclass IgA1 and mainly expressed by an excess of monomers.

Citing Articles

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Intrinsic Kidney Pathology in Children and Adolescents Following COVID-19 Vaccination: A Systematic Review.

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