MicroRNAs in the Thyroid

Overview

Journal Best Pract Res Clin Endocrinol Metab

Publisher Elsevier

Specialty Endocrinology

Date 2016 Dec 8

PMID 27923454

Citations 29

Authors

Myriem Boufraqech

Joanna Klubo-Gwiezdzinska

Electron Kebebew

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs) are small non-coding RNA comprising approximately 19-25 nucleotides. miRNAs can act as tumour suppressors or oncogenes, and aberrant expression of miRNAs has been reported in several human cancers and has been associated with cancer initiation and progression. Recent evidence suggests that miRNAs play a major role in thyroid carcinogenesis. In this review, we summarize the role of miRNAs in thyroid cancer and describe the oncogenic or tumour suppressor function of miRNAs as well as their clinical utility as prognostic or diagnostic markers in thyroid cancer.

Citing Articles

Could microRNA Analysis Help in the Management of Medullary Thyroid Cancer?.

Febrero B, Ros-Madrid I, Revilla-Nuin B, Abellan M, Ruiz-Manzanera J, Gomez J Cancers (Basel). 2025; 17(4).

PMID: 40002224 PMC: 11853104. DOI: 10.3390/cancers17040629.

Evaluating the performance of multi-omics integration: a thyroid toxicity case study.

Canzler S, Schubert K, Rolle-Kampczyk U, Wang Z, Schreiber S, Seitz H Arch Toxicol. 2024; 99(1):309-332.

PMID: 39441382 PMC: 11742338. DOI: 10.1007/s00204-024-03876-2.

Unraveling the Significance of DGCR8 and miRNAs in Thyroid Carcinoma.

Rodrigues L, Da Cruz Paula A, Soares P, Vinagre J Cells. 2024; 13(7.

PMID: 38607000 PMC: 11011343. DOI: 10.3390/cells13070561.

Indeterminate Thyroid Nodules: From Cytology to Molecular Testing.

Vignali P, Macerola E, Poma A, Sparavelli R, Basolo F Diagnostics (Basel). 2023; 13(18).

PMID: 37761374 PMC: 10528553. DOI: 10.3390/diagnostics13183008.

Expressions of mitochondria-related genes in pregnant women with subclinical hypothyroidism, and expressions of miRNAs in maternal and cord blood.

Stryhn J, Larsen J, Pedersen P, Gaede P Thyroid Res. 2023; 16(1):38.

PMID: 37723507 PMC: 10506244. DOI: 10.1186/s13044-023-00180-6.

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