The Effect of Gall Extract on Burn Wound Healing in Rat

Overview

Journal Iran J Basic Med Sci

Publisher Mashhad University of Medical Sciences

Specialty General Medicine

Date 2016 Nov 23

PMID 27872712

Authors

Faraidoon Haghdoost

Mohammad Mehdi Baradaran Mahdavi

Behzad Zolfaghari

Mohammad Hossein Sanei

Somaye Najafi

Alireza Zandifar

Navid Manouchehri

Shaghayegh Haghjooy Javanmard

Affiliations

Soon will be listed here.

Abstract

Objectives: The aim of the present study was to evaluate the effect of galls extract on the rat skin burn wound healing.

Materials And Methods: Ethanol extract of the galls of was used to treat the induced burn wounds on the back of 32 Wistar rats divided into 4 groups. The groups were treated by placebo, 1%, 2% and 4% concentration gall extract gels for 14 days and the efficacy of treatment was assessed based on reduction of burn wound area, as well as histological and molecular characteristics.

Results: The mean wound surface in the 14 day, in all groups treated by gall extracts were larger than control group and the differences were statistically significant (=0.043). The mean histological wound healing scores were not statistically different. Analysis of nitric oxide and platelet derived growth factor concentration in wound fluids in the 5 day of study showed that there was not any significant difference between groups (=0.468 and 0.312 respectively). Fibroblast growth factor (bFGF) concentration in the wound fluids, was significantly higher in group treated with 1% gall extract gel in comparison to the control group (=0.026).

Conclusion: Our results could not prove the significant positive effect of galls extract on the burning wound healing. More studies with more groups treated with different doses of the extract are recommended.

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