MGluR Long-term Depression Regulates GluA2 Association with COPII Vesicles and Exit from the Endoplasmic Reticulum

Overview

Journal EMBO J

Specialties Biotechnology
Molecular Biology

Date 2016 Nov 19

PMID 27856517

Citations 18

Authors

Joseph E Pick

Latika Khatri

Matheus F Sathler

Edward B Ziff

Affiliations

Soon will be listed here.

Abstract

mGluR long-term depression (mGluR-LTD) is a form of synaptic plasticity induced at excitatory synapses by metabotropic glutamate receptors (mGluRs). mGluR-LTD reduces synaptic strength and is relevant to learning and memory, autism, and sensitization to cocaine; however, the mechanism is not known. Here we show that activation of Group I mGluRs in medium spiny neurons induces trafficking of GluA2 from the endoplasmic reticulum (ER) to the synapse by enhancing GluA2 binding to essential COPII vesicle proteins, Sec23 and Sec13. GluA2 exit from the ER further depends on IP3 and Ryanodine receptor-controlled Ca release as well as active translation. Synaptic insertion of GluA2 is coupled to removal of high-conducting Ca-permeable AMPA receptors from synapses, resulting in synaptic depression. This work demonstrates a novel mechanism in which mGluR signals release AMPA receptors rapidly from the ER and couple ER release to GluA2 synaptic insertion and GluA1 removal.

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