Polymorphism of SLC6A2 Gene Does Not Influence Outcome of Myocardial I-mIBG Scintigraphy in Patients with Chronic Heart Failure

Overview

Journal J Nucl Cardiol

Specialty Cardiology & Vascular Diseases

Date 2016 Nov 16

PMID 27844334

Citations 1

Authors

Derk O Verschure

F Baas

Berthe L F van Eck-Smit

G Aernout Somsen

Hein J Verberne

Affiliations

Soon will be listed here.

Abstract

Aim: The NET, encoded by SLC6A2, is responsible for presynaptic NE-reuptake. I-mIBG is clinically used to evaluate cardiac sympathetic function. However, it is unknown if polymorphism of SLC6A2 influences cardiac sympathetic activity as assessed with I-mIBG. Therefore we studied the influence of SLC6A2 SNPs on myocardial I-mIBG parameters in CHF.

Materials And Methods: Forty-nine adults with stable CHF (age 66.5 ± 8.1 years, LVEF 22.3 ± 6.4) were enrolled. Fifteen minutes (early) and 4 hours (late) after administration of I-mIBG planar images were acquired. The H/M ratio was calculated from the manually drawn ROI over the left ventricle and a fixed mediastinal ROI. Fourteen exons of the SLC6A2 gene were analyzed from whole blood samples.

Results: We found 6 different SLC6A2 SNPs, although none were functional. LVEF was the only independent predictor for early (adjusted R = 0.063, p = 0.045) and late H/M ratio (adjusted R = 0.116, p = 0.010). NT-proBNP was the only independent predictor for I-mIBG WO (adjusted R = 0.074, p = 0.032). SLC6A2 SNPs were not associated with any myocardial I-mIBG-derived parameter.

Conclusion: In this specific CHF population polymorphism of SLC6A2 gene was not associated with any I-mIBG derived parameters.

Citing Articles

Standardization of I--iodobenzylguanidine myocardial sympathetic activity imaging: phantom calibration and clinical applications.

Nakajima K, Verschure D, Okuda K, Verberne H Clin Transl Imaging. 2017; 5(3):255-263.

PMID: 28596948 PMC: 5437131. DOI: 10.1007/s40336-017-0230-2.

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