Wnt--Catenin Signaling Promotes the Maturation of Mast Cells

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2016 Nov 16

PMID 27843938

Citations 7

Authors

Tomoko Yamaguchi

Misae Nishijima

Katsuhisa Tashiro

Kenji Kawabata

Affiliations

Soon will be listed here.

Abstract

Mast cells play an important role in the pathogenesis of allergic diseases. Immature mast cells migrate into peripheral tissues from the bone marrow and undergo complete maturation. Interestingly, mast cells have characteristics similar to hematopoietic stem cells (HSCs), such as self-renewal and c-kit expression. In HSCs, Wnt signaling is involved in their maintenance and differentiation. On the other hand, the relation between Wnt signaling and mast cell differentiation is poorly understood. To study whether Wnt signals play a role in the maturation of mast cells, we studied the effect of Wnt proteins on mast cell maturation of bone marrow-derived mast cells (BMMCs). The expression levels of CD81 protein and histidine decarboxylase mRNA and activity of mast cell-specific protease were all elevated in BMMCs treated with Wnt5a. In addition, Wnt5a induced the expression of Axin2 and TCF mRNA in BMMCs. These results showed that Wnt5a could promote the maturation of mast cells via the canonical Wnt signaling pathway and provide important insights into the molecular mechanisms underlying the differentiation of mast cells.

Citing Articles

The molecular mechanisms of remodeling in asthma, COPD and IPF with a special emphasis on the complex role of Wnt5A.

Singla A, Reuter S, Taube C, Peters M, Peters K Inflamm Res. 2023; 72(3):577-588.

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Comparative Study of the Role of Interepithelial Mucosal Mast Cells in the Context of Intestinal Adenoma-Carcinoma Progression.

Groll T, Silva M, Sarker R, Tschurtschenthaler M, Schnalzger T, Mogler C Cancers (Basel). 2022; 14(9).

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Wnts and the hallmarks of cancer.

Zhong Z, Yu J, Virshup D, Madan B Cancer Metastasis Rev. 2020; 39(3):625-645.

PMID: 32385713 DOI: 10.1007/s10555-020-09887-6.

Cell Intrinsic Deregulated ß-Catenin Signaling Promotes Expansion of Bone Marrow Derived Connective Tissue Type Mast Cells, Systemic Inflammation, and Colon Cancer.

Saadalla A, Lima M, Tsai F, Osman A, Singh M, Linden D Front Immunol. 2019; 10:2777.

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Wnt Signaling in the Regulation of Immune Cell and Cancer Therapeutics.

Haseeb M, Pirzada R, Ain Q, Choi S Cells. 2019; 8(11).

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