A Modification of Intraluminal Middle Cerebral Artery Occlusion/reperfusion Model for Ischemic Stroke with Laser Doppler Flowmetry Guidance in Mice

Overview

Journal Neuropsychiatr Dis Treat

Publisher Dove Medical Press

Specialty Psychiatry

Date 2016 Nov 16

PMID 27843320

Citations 6

Authors

Qiang Cai

Gang Xu

Junhui Liu

Long Wang

Gang Deng

Jun Liu

Zhibiao Chen

Affiliations

Soon will be listed here.

Abstract

Stroke is one of the common causes of death and disability in the world. The intraluminal middle cerebral artery occlusion/reperfusion (MCAO/R) model is a "gold standard" in surgical ischemic stroke models. Here, we optimized the procedure of this model by ligating on external carotid artery (ECA) stump and two ligatures prepared on internal carotid artery, which could improve the success and survival rate in mice. The results show that ECA approach was superior to common carotid artery approach. Meanwhile, we found that the exposure of pterygopalatine artery was not an essential step for MCAO/R model in mice.

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