Tracing the Cellular Origin of Cancer

Overview

Journal Nat Cell Biol

Specialty Cell Biology

Date 2013 Jan 22

PMID 23334500

Citations 132

Authors

Cedric Blanpain

Affiliations

Soon will be listed here.

Abstract

Although many genes that lead to different types of cancer when mutated have been identified, the cells that initiate tumour formation following accumulation of these mutations have, until recently, remained elusive. This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncogenes and/or the deletion of tumour suppressor genes in defined cell lineages have been instrumental in defining the cellular origin of different solid tumours in mouse models for various human cancers.

Citing Articles

Cell signaling communication within papillary craniopharyngioma revealed by an integrated analysis of single-cell RNA sequencing and bulk RNA sequencing.

Zhu X, Jia Y, Zhao Z, Zhang X, Zhao Y, Gui S J Transl Med. 2025; 23(1):124.

PMID: 39871369 PMC: 11773883. DOI: 10.1186/s12967-025-06149-3.

Cancer Stem Cells in Oral Squamous Cell Carcinoma: A Narrative Review on Experimental Characteristics and Methodological Challenges.

Acharya S, Shai S, Choon Y, Gunardi I, Hartanto F, Kadir K Biomedicines. 2024; 12(9).

PMID: 39335624 PMC: 11429394. DOI: 10.3390/biomedicines12092111.

CCKBR+ cancer cells contribute to the intratumor heterogeneity of gastric cancer and confer sensitivity to FOXO inhibition.

Tan Z, Pan K, Sun M, Pan X, Yang Z, Chang Z Cell Death Differ. 2024; 31(10):1302-1317.

PMID: 39164456 PMC: 11445462. DOI: 10.1038/s41418-024-01360-z.

ScRNA-seq revealed the tumor microenvironment heterogeneity related to the occurrence and metastasis in upper urinary tract urothelial carcinoma.

Xin S, Zhang Y, Zhang Z, Li Z, Sun X, Liu X Cancer Gene Ther. 2024; 31(8):1201-1220.

PMID: 38877164 DOI: 10.1038/s41417-024-00779-3.

Trefoil factor 1 suppresses stemness and enhances chemosensitivity of pancreatic cancer.

Yamaguchi J, Kokuryo T, Yokoyama Y, Oishi S, Sunagawa M, Mizuno T Cancer Med. 2024; 13(11):e7395.

PMID: 38872370 PMC: 11176577. DOI: 10.1002/cam4.7395.

References

Rock J, Onaitis M, Rawlins E, Lu Y, Clark C, Xue Y . Basal cells as stem cells of the mouse trachea and human airway epithelium. Proc Natl Acad Sci U S A. 2009; 106(31):12771-5. PMC: 2714281. DOI: 10.1073/pnas.0906850106. View

Korinek V, Barker N, Morin P, van Wichen D, de Weger R, Kinzler K . Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science. 1997; 275(5307):1784-7. DOI: 10.1126/science.275.5307.1784. View

Choi N, Zhang B, Zhang L, Ittmann M, Xin L . Adult murine prostate basal and luminal cells are self-sustained lineages that can both serve as targets for prostate cancer initiation. Cancer Cell. 2012; 21(2):253-65. PMC: 3285423. DOI: 10.1016/j.ccr.2012.01.005. View

Kinzler K, Vogelstein B . Lessons from hereditary colorectal cancer. Cell. 1996; 87(2):159-70. DOI: 10.1016/s0092-8674(00)81333-1. View

Doupe D, Klein A, Simons B, Jones P . The ordered architecture of murine ear epidermis is maintained by progenitor cells with random fate. Dev Cell. 2010; 18(2):317-23. DOI: 10.1016/j.devcel.2009.12.016. View

Montgomery R, Carlone D, Richmond C, Farilla L, Kranendonk M, Henderson D . Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells. Proc Natl Acad Sci U S A. 2010; 108(1):179-84. PMC: 3017192. DOI: 10.1073/pnas.1013004108. View

Chen J, Li Y, Yu T, McKay R, Burns D, Kernie S . A restricted cell population propagates glioblastoma growth after chemotherapy. Nature. 2012; 488(7412):522-6. PMC: 3427400. DOI: 10.1038/nature11287. View

Rawlins E, Okubo T, Xue Y, Brass D, Auten R, Hasegawa H . The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium. Cell Stem Cell. 2009; 4(6):525-34. PMC: 2730729. DOI: 10.1016/j.stem.2009.04.002. View

Van Keymeulen A, Mascre G, Youseff K, Harel I, Michaux C, De Geest N . Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasis. J Cell Biol. 2009; 187(1):91-100. PMC: 2762088. DOI: 10.1083/jcb.200907080. View

10.

Beasley M, Lantuejoul S, Abbondanzo S, Chu W, Hasleton P, Travis W . The P16/cyclin D1/Rb pathway in neuroendocrine tumors of the lung. Hum Pathol. 2003; 34(2):136-42. DOI: 10.1053/hupa.2003.8. View

11.

Xin L, Lukacs R, Lawson D, Cheng D, Witte O . Self-renewal and multilineage differentiation in vitro from murine prostate stem cells. Stem Cells. 2007; 25(11):2760-9. DOI: 10.1634/stemcells.2007-0355. View

12.

Pei Y, Moore C, Wang J, Tewari A, Eroshkin A, Cho Y . An animal model of MYC-driven medulloblastoma. Cancer Cell. 2012; 21(2):155-67. PMC: 3285431. DOI: 10.1016/j.ccr.2011.12.021. View

13.

Wang G, Wang J, Mancianti M, Epstein Jr E . Basal cell carcinomas arise from hair follicle stem cells in Ptch1(+/-) mice. Cancer Cell. 2011; 19(1):114-24. PMC: 3061401. DOI: 10.1016/j.ccr.2010.11.007. View

14.

Merlo L, Pepper J, Reid B, Maley C . Cancer as an evolutionary and ecological process. Nat Rev Cancer. 2006; 6(12):924-35. DOI: 10.1038/nrc2013. View

15.

Visvader J . Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis. Genes Dev. 2009; 23(22):2563-77. PMC: 2779757. DOI: 10.1101/gad.1849509. View

16.

Barker N, Bartfeld S, Clevers H . Tissue-resident adult stem cell populations of rapidly self-renewing organs. Cell Stem Cell. 2010; 7(6):656-70. DOI: 10.1016/j.stem.2010.11.016. View

17.

Wang X, Kruithof-de Julio M, Economides K, Walker D, Yu H, Halili M . A luminal epithelial stem cell that is a cell of origin for prostate cancer. Nature. 2009; 461(7263):495-500. PMC: 2800362. DOI: 10.1038/nature08361. View

18.

Hanahan D, Weinberg R . Hallmarks of cancer: the next generation. Cell. 2011; 144(5):646-74. DOI: 10.1016/j.cell.2011.02.013. View

19.

Grachtchouk M, Pero J, Yang S, Ermilov A, Michael L, Wang A . Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations. J Clin Invest. 2011; 121(5):1768-81. PMC: 3083781. DOI: 10.1172/JCI46307. View

20.

Trotman L, Niki M, Dotan Z, Koutcher J, Di Cristofano A, Xiao A . Pten dose dictates cancer progression in the prostate. PLoS Biol. 2003; 1(3):E59. PMC: 270016. DOI: 10.1371/journal.pbio.0000059. View