Insights into Inner Ear-specific Gene Regulation: Epigenetics and Non-coding RNAs in Inner Ear Development and Regeneration

Overview

Journal Semin Cell Dev Biol

Specialties Cell Biology
Reproductive Medicine

Date 2016 Nov 13

PMID 27836639

Citations 16

Authors

Angelika Doetzlhofer

Karen B Avraham

Affiliations

Soon will be listed here.

Abstract

The vertebrate inner ear houses highly specialized sensory organs, tuned to detect and encode sound, head motion and gravity. Gene expression programs under the control of transcription factors orchestrate the formation and specialization of the non-sensory inner ear labyrinth and its sensory constituents. More recently, epigenetic factors and non-coding RNAs emerged as an additional layer of gene regulation, both in inner ear development and disease. In this review, we provide an overview on how epigenetic modifications and non-coding RNAs, in particular microRNAs (miRNAs), influence gene expression and summarize recent discoveries that highlight their critical role in the proper formation of the inner ear labyrinth and its sensory organs. Finally, we discuss recent insights into how epigenetic factors and miRNAs may facilitate, or in the case of mammals, restrict inner ear sensory hair cell regeneration.

Citing Articles

The role of epigenetic modifications in sensory hair cell development, survival, and regulation.

Xiao Y, Li D Front Cell Neurosci. 2023; 17:1210279.

PMID: 37388412 PMC: 10300351. DOI: 10.3389/fncel.2023.1210279.

Transcriptomic and epigenomic analyses explore the potential role of H3K4me3 in neomycin-induced cochlear Lgr5+ progenitor cell regeneration of hair cells.

Ma X, Zhang S, Qin S, Guo J, Yuan J, Qiang R Hum Cell. 2022; 35(4):1030-1044.

PMID: 35668241 DOI: 10.1007/s13577-022-00727-z.

Single-cell transcriptome analysis reveals three sequential phases of gene expression during zebrafish sensory hair cell regeneration.

Baek S, Tran N, Diaz D, Tsai Y, Acedo J, Lush M Dev Cell. 2022; 57(6):799-819.e6.

PMID: 35316618 PMC: 9188816. DOI: 10.1016/j.devcel.2022.03.001.

Molecular Pathways Modulating Sensory Hair Cell Regeneration in Adult Mammalian Cochleae: Progress and Perspectives.

Rai V, Tu S, Frank J, Zuo J Int J Mol Sci. 2022; 23(1).

PMID: 35008497 PMC: 8745006. DOI: 10.3390/ijms23010066.

Genetics & Epigenetics of Hereditary Deafness: An Historical Overview.

Martini A, Sorrentino F, Sorrentino U, Cassina M Audiol Res. 2021; 11(4):629-635.

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