Caveolin-1 Regulation of Disrupted-in-schizophrenia-1 As a Potential Therapeutic Target for Schizophrenia

Overview

Journal J Neurophysiol

Publisher American Physiological Society

Specialties Neurology
Physiology

Date 2016 Nov 11

PMID 27832597

Citations 18

Authors

Adam Kassan

Junji Egawa

Zheng Zhang

Angels Almenar-Queralt

Quynh My Nguyen

Yasaman Lajevardi

Kaitlyn Kim

Edmund Posadas

Dilip V Jeste

David M Roth

Piyush M Patel

Hemal H Patel

Brian P Head

Affiliations

Soon will be listed here.

Abstract

New & Noteworthy: The present study is the first to demonstrate that caveolin-1 can regulate DISC1 expression in neuronal models. Furthermore, the findings are consistent across three separate neuronal models that include rodent neurons (in vitro and in vivo) and human differentiated neurons derived from induced pluripotent stem cells. These findings justify further investigation regarding the modulatory role by caveolin on synaptic function and as a potential therapeutic target for the treatment of schizophrenia.

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