Association of Serum 25-hydroxyvitamin D Status with Bone Mineral Density in 0-7 Year Old Children

Overview

Journal Oncotarget

Specialty Oncology

Date 2016 Nov 9

PMID 27821808

Citations 7

Authors

Yanrong Fu

Youfang Hu

Zhenying Qin

Yan Zhao

Zi Yang

Yinfang Li

Guanyu Liang

Heyun Lv

Hong Hong

Yuan Song

Yarong Wei

Hongni Yue

Wen Zheng

Guoqin Liu

Yufei Ni

Mei Zhu

Aiping Wu

Juhua Yan

Chenbo Ji

Xirong Guo

Juan Wen

Rui Qin

Affiliations

Soon will be listed here.

Abstract

Objective: To describe the status of serum 25-hydoxyvitamin D [25(OH)D] concentrations and identify the relationship between 25(OH)D and bone mineral density (BMD). In an effort to explore the appropriate definition of vitamin D (VD) deficiency in 0-7 year old children.

Results: The median serum 25(OH)D concentrations was 62.9 nmol/L and 28.9% of the children had a low 25(OH)D (< 50 nmol/L). And a linear relation between 25(OH)D concentrations and BMD was surveyed (r = 0.144 , P < 0.001). After adjusting for the confounders, serum 25(OH)D was positively associated with BMD (β = 172.0, 95%CI = 142.8-201.2, P < 0.001), and low 25(OH)D (< 75 nmol/L) had a high stake for low BMD (OR = 1.424, 95%CI = 1.145-1.769, P = 0.001). Additionally, there was a nonlinear relation between 25(OH)D and low BMD, and a critical value for 25(OH)D of 75 nmol/L appeared for low BMD. The prevalence of low BMD was 14.1% in children with 25(OH)D ≥ 75 nmol/L, much lower than that of the concentrations between 50-75 nmol/L and < 50 nmol/L.

Materials And Methods: A total of 4,846 children 0-7 years old were recruited in Jiangsu Province, China. BMD and serum 25(OH)D concentrations were determined by quantitative ultrasound and enzyme-linked immunosorbent assay, respectively. Linear regression and logistic regression analyses were used to assess the association of 25(OH)D concentrations with BMD.

Conclusions: Serum 25(OH)D concentrations was related with BMD and 25(OH)D concentrations < 75 nmol/L might be a more appropriate definition of VD deficiency in 0-7 year old children.

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