β-Lactamase Inhibitors Enhance the Synergy Between β-Lactam Antibiotics and Daptomycin Against Methicillin-Resistant Staphylococcus Aureus

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2016 Nov 9

PMID 27821441

Citations 5

Authors

Karl Evans R Henson

Juwon Yim

Jordan R Smith

George Sakoulas

Michael J Rybak

Affiliations

Soon will be listed here.

Abstract

The evidence for using combination therapy for the treatment of serious methicillin-resistant Staphylococcus aureus (MRSA) infections is growing. In this study, we investigated the synergistic effect of daptomycin (DAP) combined with piperacillin-tazobactam and ampicillin-sulbactam against MRSA in time-kill experiments. Six of eight strains demonstrated synergy between DAP and the β-lactam-β-lactamase inhibitor (BLI) combination. In 5/8 strains, the synergy occurred only in the presence of the BLI, highlighting a role for BLIs in peptide-β-lactam synergy.

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