Macrophage Migration Inhibitory Factor: a Potential Driver and Biomarker for Head and Neck Squamous Cell Carcinoma

Overview

Journal Oncotarget

Specialty Oncology

Date 2016 Oct 28

PMID 27788497

Citations 10

Authors

Sha-Sha Wang

Xiao Cen

Xin-Hua Liang

Ya-Ling Tang

Affiliations

Soon will be listed here.

Abstract

Macrophage migration inhibitory factor (MIF), a pleiotropic proinflammatory cytokine, has been showed to be associated with the immunopathogenesis of many diseases. Recent study demonstrated that MIF promoted tumorigenesis and tumor progression and played a critical role in various kinds of human cancer including head and neck squamous cell carcinoma(HNSCC). Hence, in this paper we retrospected the relationship between MIF and angiogenesis, epithelial-mesenchymal transition (EMT), inflammation, immune response, hypoxia microenvironment, and discussed whether it is a promising biomarker for diagnosis and supervisor of HNSCC.

Citing Articles

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Macrophage Migration Inhibitory Factor (MIF) and D-Dopachrome Tautomerase (DDT): Pathways to Tumorigenesis and Therapeutic Opportunities.

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The Crossroads of Periodontitis and Oral Squamous Cell Carcinoma: Immune Implications and Tumor Promoting Capacities.

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