Salbutamol Effects on Systemic Potassium Dynamics During and Following Intense Continuous and Intermittent Exercise

Overview

Journal Eur J Appl Physiol

Specialty Physiology

Date 2016 Oct 25

PMID 27771799

Citations 4

Authors

Muath M Altarawneh

Aaron Petersen

Robert Smith

David M Rouffet

Francois Billaut

Ben D Perry

Victoria L Wyckelsma

Antony Tobin

Michael J McKenna

Affiliations

Soon will be listed here.

Abstract

Purpose: Salbutamol inhalation is permissible by WADA in athletic competition for asthma management and affects potassium regulation, which is vital for muscle function. Salbutamol effects on arterial potassium concentration ([K]) during and after high-intensity continuous exercise (HI) and intermittent exercise comprising repeated, brief sprints (HI), and on performance during HI are unknown and were investigated.

Methods: Seven recreationally active men participated in a double-blind, randomised, cross-over design, inhaling 1000 µg salbutamol or placebo. Participants cycled continuously for 5 min at 40 % [Formula: see text]O and 60 % [Formula: see text]O, then HI (90 s at 130 % [Formula: see text]O), 20 min recovery, and then HI (3 sets, 5 × 4 s sprints), with 30 min recovery.

Results: Plasma [K] increased throughout exercise and subsequently declined below baseline (P < 0.001). Plasma [K] was greater during HI than HI (P < 0.001, HI 5.94 ± 0.65 vs HI set 1, 4.71 ± 0.40 mM); the change in [K] from baseline (Δ[K]) was 2.6-fold greater during HI than HI (P < 0.001). The Δ[K] throughout the trial was less with salbutamol than placebo (P < 0.001, treatment main effect, 0.03 ± 0.67 vs 0.22 ± 0.69 mM, respectively); and remained less after correction for fluid shifts (P < 0.001). The Δ[K] during HI was less after salbutamol (P < 0.05), but not during HI. Blood lactate, plasma pH, and the work output during HI did not differ between trials.

Conclusions: Inhaled salbutamol modulated the [K] rise across the trial, comprising intense continuous and intermittent exercise and recovery, lowering Δ[K] during HI. The limited [K] changes during HI suggest that salbutamol is unlikely to influence systemic [K] during periods of intense effort in intermittent sports.

Citing Articles

A century of exercise physiology: effects of muscle contraction and exercise on skeletal muscle Na,K-ATPase, Na and K ions, and on plasma K concentration-historical developments.

McKenna M, Renaud J, Ortenblad N, Overgaard K Eur J Appl Physiol. 2024; 124(3):681-751.

PMID: 38206444 PMC: 10879387. DOI: 10.1007/s00421-023-05335-9.

Oral digoxin effects on exercise performance, K regulation and skeletal muscle Na ,K -ATPase in healthy humans.

Sostaric S, Petersen A, Goodman C, Gong X, Aw T, Brown M J Physiol. 2022; 600(16):3749-3774.

PMID: 35837833 PMC: 9541254. DOI: 10.1113/JP283017.

A single oral glucose load decreases arterial plasma [K ] during exercise and recovery.

Steward C, Smith R, Stepto N, Brown M, Ng I, McKenna M Physiol Rep. 2021; 9(11):e14889.

PMID: 34110701 PMC: 8191174. DOI: 10.14814/phy2.14889.

Regulation of muscle potassium: exercise performance, fatigue and health implications.

Lindinger M, Cairns S Eur J Appl Physiol. 2021; 121(3):721-748.

PMID: 33392745 DOI: 10.1007/s00421-020-04546-8.

References

Gullestad L, Hallen J, Sejersted O . K+ balance of the quadriceps muscle during dynamic exercise with and without beta-adrenoceptor blockade. J Appl Physiol (1985). 1995; 78(2):513-23. DOI: 10.1152/jappl.1995.78.2.513. View

Hostrup M, Kalsen A, Bangsbo J, Hemmersbach P, Karlsson S, Backer V . High-dose inhaled terbutaline increases muscle strength and enhances maximal sprint performance in trained men. Eur J Appl Physiol. 2014; 114(12):2499-508. DOI: 10.1007/s00421-014-2970-2. View

Bennett J, Tattersfield A . Time course and relative dose potency of systemic effects from salmeterol and salbutamol in healthy subjects. Thorax. 1997; 52(5):458-64. PMC: 1758570. DOI: 10.1136/thx.52.5.458. View

Collomp K, Le Panse B, Portier H, Lecoq A, Jaffre C, Beaupied H . Effects of acute salbutamol intake during a Wingate test. Int J Sports Med. 2005; 26(7):513-7. DOI: 10.1055/s-2004-821223. View

Clausen T . Excitation-induced exchange of Na+, K+, and Cl- in rat EDL muscle in vitro and in vivo: physiology and pathophysiology. J Gen Physiol. 2013; 141(2):179-92. PMC: 3557307. DOI: 10.1085/jgp.201210892. View

Leitch A, Clancy L, Costello J, Flenley D . Effect of intravenous infusion of salbutamol on ventilatory response to carbon dioxide and hypoxia and on heart rate and plasma potassium in normal men. Br Med J. 1976; 1(6006):365-7. PMC: 1638778. DOI: 10.1136/bmj.1.6006.365. View

McDonough A, Youn J . Role of muscle in regulating extracellular [K+]. Semin Nephrol. 2005; 25(5):335-42. DOI: 10.1016/j.semnephrol.2005.03.009. View

Krustrup P, Mohr M, Steensberg A, Bencke J, Kjaer M, Bangsbo J . Muscle and blood metabolites during a soccer game: implications for sprint performance. Med Sci Sports Exerc. 2006; 38(6):1165-74. DOI: 10.1249/01.mss.0000222845.89262.cd. View

Tobin A, Pellizzer A, Santamaria J . Mechanisms by which systemic salbutamol increases ventilation. Respirology. 2006; 11(2):182-7. DOI: 10.1111/j.1440-1843.2006.00832.x. View

10.

McKenna M, Gissel H, Clausen T . Effects of electrical stimulation and insulin on Na+-K+-ATPase ([3H]ouabain binding) in rat skeletal muscle. J Physiol. 2003; 547(Pt 2):567-80. PMC: 2342648. DOI: 10.1113/jphysiol.2003.034512. View

11.

Atanasovska T, Petersen A, Rouffet D, Billaut F, Ng I, McKenna M . Plasma K+ dynamics and implications during and following intense rowing exercise. J Appl Physiol (1985). 2014; 117(1):60-8. DOI: 10.1152/japplphysiol.01027.2013. View

12.

Struthers A, Quigley C, Brown M . Rapid changes in plasma potassium during a game of squash. Clin Sci (Lond). 1988; 74(4):397-401. DOI: 10.1042/cs0740397. View

13.

Wylie L, Mohr M, Krustrup P, Jackman S, Ermidis G, Kelly J . Dietary nitrate supplementation improves team sport-specific intense intermittent exercise performance. Eur J Appl Physiol. 2013; 113(7):1673-84. DOI: 10.1007/s00421-013-2589-8. View

14.

van Baak M, Mayer L, Kempinski R, Hartgens F . Effect of salbutamol on muscle strength and endurance performance in nonasthmatic men. Med Sci Sports Exerc. 2000; 32(7):1300-6. DOI: 10.1097/00005768-200007000-00018. View

15.

Edner M, Jogestrand T . Oral salbutamol decreases serum digoxin concentration. Eur J Clin Pharmacol. 1990; 38(2):195-7. DOI: 10.1007/BF00265984. View

16.

Bishop D, Girard O, Mendez-Villanueva A . Repeated-sprint ability - part II: recommendations for training. Sports Med. 2011; 41(9):741-56. DOI: 10.2165/11590560-000000000-00000. View

17.

McKenna M, Schmidt T, Hargreaves M, Cameron L, Skinner S, Kjeldsen K . Sprint training increases human skeletal muscle Na(+)-K(+)-ATPase concentration and improves K+ regulation. J Appl Physiol (1985). 1993; 75(1):173-80. DOI: 10.1152/jappl.1993.75.1.173. View

18.

MANDELBERG A, Krupnik Z, Houri S, Smetana S, Gilad E, Matas Z . Salbutamol metered-dose inhaler with spacer for hyperkalemia: how fast? How safe?. Chest. 1999; 115(3):617-22. DOI: 10.1378/chest.115.3.617. View

19.

Koch S, Ahn J, Koehle M . High-Dose Inhaled Salbutamol Does Not Improve 10-km Cycling Time Trial Performance. Med Sci Sports Exerc. 2015; 47(11):2373-9. DOI: 10.1249/MSS.0000000000000679. View

20.

Lindinger M, McKelvie R, Heigenhauser G . K+ and Lac- distribution in humans during and after high-intensity exercise: role in muscle fatigue attenuation?. J Appl Physiol (1985). 1995; 78(3):765-77. DOI: 10.1152/jappl.1995.78.3.765. View