Michael J McKenna
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Explore the profile of Michael J McKenna including associated specialties, affiliations and a list of published articles.
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171
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2704
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Recent Articles
1.
Atanasovska T, Farr T, Smith R, Petersen A, Garnham A, Andersen M, et al.
J Physiol
. 2024 Nov;
602(24):6849-6869.
PMID: 39580613
We investigated acute effects of the Na,K-ATPase (NKA) inhibitor, digoxin, on muscle NKA content and isoforms, arterial plasma [K] ([K]) and fatigue with intense exercise. In a randomised, crossover, double-blind...
2.
McKenna M, Gong X, Petersen A, Sostaric S, Goodman C, Garnham A, et al.
Exp Physiol
. 2024 Sep;
109(11):1909-1921.
PMID: 39222217
In muscle, digoxin inhibits Na,K-ATPase (NKA) whereas acute exercise can increase NKA gene expression, consistent with training-induced increased NKA content. We investigated whether oral digoxin increased NKA isoform mRNA expression...
3.
Pascoe M, Patten R, Tacey A, Woessner M, Bourke M, Bennell K, et al.
PLOS Glob Public Health
. 2024 Jul;
4(7):e0003129.
PMID: 39024243
Osteoarthritis is a leading cause of chronic pain and is associated with high rates of depression. Physical activity reduces depression symptoms and pain levels. It remains unknown if physical activity...
4.
McKenna M, Renaud J, Ortenblad N, Overgaard K
Eur J Appl Physiol
. 2024 Jan;
124(3):681-751.
PMID: 38206444
This historical review traces key discoveries regarding K and Na ions in skeletal muscle at rest and with exercise, including contents and concentrations, Na,K-ATPase (NKA) and exercise effects on plasma...
5.
Tacey A, Behne J, Patten R, Ngo M, Thomas R, Ancilleri J, et al.
JMIR Form Res
. 2023 Dec;
7:e41974.
PMID: 38064257
Background: The demand for orthopedic specialist consultations for patients with osteoarthritis in public hospitals is high and continues to grow. Lengthy waiting times are increasingly affecting patients from low socioeconomic...
6.
Renaud J, Ortenblad N, McKenna M, Overgaard K
Eur J Appl Physiol
. 2023 Aug;
123(11):2345-2378.
PMID: 37584745
Perturbations in K have long been considered a key factor in skeletal muscle fatigue. However, the exercise-induced changes in K intra-to-extracellular gradient is by itself insufficiently large to be a...
7.
Patten R, Asilioglu A, Levinger I, Tacey A, Pascoe M, Tran P, et al.
BMC Musculoskelet Disord
. 2023 Jul;
24(1):599.
PMID: 37481532
Background: Musculoskeletal conditions, including osteoarthritis (OA), are a leading cause of disability and chronic pain, and are associated with high rates of comorbid depression. However, signs of depression are often...
8.
McKenna M, Adams B, Chu V, Paulo J, Shao S
Mol Cell
. 2022 Oct;
82(22):4277-4289.e10.
PMID: 36283413
The biosynthesis of thousands of proteins requires targeting a signal sequence or transmembrane segment (TM) to the endoplasmic reticulum (ER). These hydrophobic ɑ helices must localize to the appropriate cellular...
9.
Wells D, Knoll R, Kozin E, Chen J, Reinshagen K, Staecker H, et al.
Otol Neurotol
. 2022 Sep;
43(9):e957-e962.
PMID: 36075107
Introduction: Internal auditory canal (IAC) diverticula, also known as IAC cavitary lesions or anterior cupping of the IAC, observed in otopathologic specimens and high-resolution computed tomography (CT) scans of the...
10.
McKenna M, Shao S
Cold Spring Harb Perspect Biol
. 2022 Aug;
15(3).
PMID: 36041782
High-fidelity protein localization is essential to define the identities and functions of different organelles and to maintain cellular homeostasis. Accurate localization of nascent proteins requires specific protein targeting pathways as...