Anionic Oligothiophenes Compete for Binding of X-34 but Not PIB to Recombinant Aβ Amyloid Fibrils and Alzheimer's Disease Brain-Derived Aβ

Overview

Journal Chemistry

Specialty Chemistry

Date 2016 Nov 4

PMID 27767229

Citations 14

Authors

Marcus Back

Hanna Appelqvist

Harry LeVine 3rd

K Peter R Nilsson

Affiliations

Soon will be listed here.

Abstract

Deposits comprised of amyloid-β (Aβ) are one of the pathological hallmarks of Alzheimer's disease (AD) and small hydrophobic ligands targeting these aggregated species are used clinically for the diagnosis of AD. Herein, we observed that anionic oligothiophenes efficiently displaced X-34, a Congo Red analogue, but not Pittsburgh compound B (PIB) from recombinant Aβ amyloid fibrils and Alzheimer's disease brain-derived Aβ. Overall, we foresee that the oligothiophene scaffold offers the possibility to develop novel high-affinity ligands for Aβ pathology only found in human AD brain, targeting a different site than PIB.

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