Expression of the Cell-cell Adhesion Glycoprotein Cell-CAM 120/80 in Normal Human Tissues and Tumors

Overview

Journal Am J Pathol

Publisher Elsevier

Specialty Pathology

Date 1989 Jul 1

PMID 2774055

Citations 41

Authors

S Eidelman

C H Damsky

M J Wheelock

I Damjanov

Affiliations

Soon will be listed here.

Abstract

Polyclonal and monoclonal antibodies raised to the 80 kd glycoprotein component of the cell to cell adhesion molecule cell-CAM 120/80 were used to map its distribution immunohistochemically in normal human tissues and in benign and malignant tumors. Cell-CAM 120/80 was found in all normal epithelial tissues, but was not expressed on neural, lymphoid, smooth, striated and cardiac muscle, connective tissue, or the germ cells in either sex. The expression of this adhesion molecule was polarized in ductal and glandular epithelia and evenly circumferential in squamous and transitional epithelia. Some organs, such as the kidney, liver and endocrine glands, showed unique organ to tissue specific patterns. Maturation-dependent loss of cell-CAM 120/80 was noticed in superficial layers of squamous epithelium and the placenta. Benign epithelial tumors expressed cell-CAM 120/80 in a manner comparable with their tissue of origin. Malignant tumors expressed cell-CAM 120/80 either in a manner similar to the tissue of their origin or assumed a less polarized phenotype. Overall, the immunoreactivity in many malignant tumors appeared weaker and the polarization was less pronounced. Thus, cell-CAM 120/80 is a universal marker of human epithelial cells, but its mode of expression differs in various anatomic sites, and may be influenced by maturation or malignant transformation of cells.

Citing Articles

Examination of FERMT1 expression in placental chorionic villi and its role in HTR8-SVneo cell invasion.

Kawamura E, Hamilton G, Miskiewicz E, MacPhee D Histochem Cell Biol. 2021; 155(6):669-681.

PMID: 33683437 DOI: 10.1007/s00418-021-01977-y.

Development of surface functionalization strategies for 3D-printed polystyrene constructs.

Lerman M, Muramoto S, Arumugasaamy N, Van Order M, Lembong J, Gerald A J Biomed Mater Res B Appl Biomater. 2019; 107(8):2566-2578.

PMID: 30821930 PMC: 10320806. DOI: 10.1002/jbm.b.34347.

Fermitin family homolog-2 (FERMT2) is highly expressed in human placental villi and modulates trophoblast invasion.

Kawamura E, Hamilton G, Miskiewicz E, MacPhee D BMC Dev Biol. 2018; 18(1):19.

PMID: 30382829 PMC: 6211606. DOI: 10.1186/s12861-018-0178-0.

Heme-mediated apoptosis and fusion damage in BeWo trophoblast cells.

Liu M, Hassana S, Stiles J Sci Rep. 2016; 6:36193.

PMID: 27796349 PMC: 5086917. DOI: 10.1038/srep36193.

Role of cd56 and e-cadherin expression in the differential diagnosis of papillary thyroid carcinoma and suspected follicular-patterned lesions of the thyroid: the prognostic importance of e-cadherin.

Ceyran A, Senol S, Cobanoglu Simsek B, Sagiroglu J, Aydin A Int J Clin Exp Pathol. 2015; 8(4):3670-80.

PMID: 26097548 PMC: 4466935.

References

Hyafil F, Morello D, Babinet C, Jacob F . A cell surface glycoprotein involved in the compaction of embryonal carcinoma cells and cleavage stage embryos. Cell. 1980; 21(3):927-34. DOI: 10.1016/0092-8674(80)90456-0. View

Edelman G, Murray B, Mege R, Cunningham B, Gallin W . Cellular expression of liver and neural cell adhesion molecules after transfection with their cDNAs results in specific cell-cell binding. Proc Natl Acad Sci U S A. 1987; 84(23):8502-6. PMC: 299572. DOI: 10.1073/pnas.84.23.8502. View

Damjanov I, Andrews P . Ultrastructural differentiation of a clonal human embryonal carcinoma cell line in vitro. Cancer Res. 1983; 43(5):2190-8. View

Osborn M, Weber K . Tumor diagnosis by intermediate filament typing: a novel tool for surgical pathology. Lab Invest. 1983; 48(4):372-94. View

Damsky C, Richa J, Solter D, Knudsen K, Buck C . Identification and purification of a cell surface glycoprotein mediating intercellular adhesion in embryonic and adult tissue. Cell. 1983; 34(2):455-66. DOI: 10.1016/0092-8674(83)90379-3. View

Imhof B, Vollmers H, Goodman S, Birchmeier W . Cell-cell interaction and polarity of epithelial cells: specific perturbation using a monoclonal antibody. Cell. 1983; 35(3 Pt 2):667-75. DOI: 10.1016/0092-8674(83)90099-5. View

Suzuki N, Takeichi M . Molecular nature of the calcium-dependent cell-cell adhesion system in mouse teratocarcinoma and embryonic cells studied with a monoclonal antibody. Dev Biol. 1984; 101(1):19-27. DOI: 10.1016/0012-1606(84)90112-x. View

Thiery J, Delouvee A, Gallin W, Cunningham B, Edelman G . Ontogenetic expression of cell adhesion molecules: L-CAM is found in epithelia derived from the three primary germ layers. Dev Biol. 1984; 102(1):61-78. DOI: 10.1016/0012-1606(84)90175-1. View

Vestweber D, Kemler R . Rabbit antiserum against a purified surface glycoprotein decompacts mouse preimplantation embryos and reacts with specific adult tissues. Exp Cell Res. 1984; 152(1):169-78. DOI: 10.1016/0014-4827(84)90241-6. View

10.

Boller K, Vestweber D, Kemler R . Cell-adhesion molecule uvomorulin is localized in the intermediate junctions of adult intestinal epithelial cells. J Cell Biol. 1985; 100(1):327-32. PMC: 2113467. DOI: 10.1083/jcb.100.1.327. View

11.

Miettinen M, Virtanen I, Talerman A . Intermediate filament proteins in human testis and testicular germ-cell tumors. Am J Pathol. 1985; 120(3):402-10. PMC: 1887981. View

12.

Edelman G . Expression of cell adhesion molecules during embryogenesis and regeneration. Exp Cell Res. 1985; 161(1):1-16. DOI: 10.1016/0014-4827(85)90485-9. View

13.

Richa J, Damsky C, Buck C, Knowles B, Solter D . Cell surface glycoproteins mediate compaction, trophoblast attachment, and endoderm formation during early mouse development. Dev Biol. 1985; 108(2):513-21. DOI: 10.1016/0012-1606(85)90054-5. View

14.

Schuh R, Vestweber D, Riede I, Ringwald M, Rosenberg U, Jackle H . Molecular cloning of the mouse cell adhesion molecule uvomorulin: cDNA contains a B1-related sequence. Proc Natl Acad Sci U S A. 1986; 83(5):1364-8. PMC: 323076. DOI: 10.1073/pnas.83.5.1364. View

15.

Damjanov I, Damjanov A, Damsky C . Developmentally regulated expression of the cell-cell adhesion glycoprotein cell-CAM 120/80 in peri-implantation mouse embryos and extraembryonic membranes. Dev Biol. 1986; 116(1):194-202. DOI: 10.1016/0012-1606(86)90056-4. View

16.

Nose A, Takeichi M . A novel cadherin cell adhesion molecule: its expression patterns associated with implantation and organogenesis of mouse embryos. J Cell Biol. 1986; 103(6 Pt 2):2649-58. PMC: 2114609. DOI: 10.1083/jcb.103.6.2649. View

17.

Edelman G . Cell adhesion molecules in the regulation of animal form and tissue pattern. Annu Rev Cell Biol. 1986; 2:81-116. DOI: 10.1146/annurev.cb.02.110186.000501. View

18.

Gallin W, Sorkin B, Edelman G, Cunningham B . Sequence analysis of a cDNA clone encoding the liver cell adhesion molecule, L-CAM. Proc Natl Acad Sci U S A. 1987; 84(9):2808-12. PMC: 304748. DOI: 10.1073/pnas.84.9.2808. View

19.

Ringwald M, Schuh R, Vestweber D, Eistetter H, Lottspeich F, Engel J . The structure of cell adhesion molecule uvomorulin. Insights into the molecular mechanism of Ca2+-dependent cell adhesion. EMBO J. 1987; 6(12):3647-53. PMC: 553833. DOI: 10.1002/j.1460-2075.1987.tb02697.x. View

20.

Odin P, Asplund M, Busch C, Obrink B . Immunohistochemical localization of cellCAM 105 in rat tissues: appearance in epithelia, platelets, and granulocytes. J Histochem Cytochem. 1988; 36(7):729-39. DOI: 10.1177/36.7.3290331. View