Highly Prevalence of Vitamin D Deficiency Among Brazilian Women of Reproductive Age

Overview

Journal Arch Endocrinol Metab

Specialty Endocrinology

Date 2016 Oct 14

PMID 27737331

Citations 17

Authors

Vinicius Medina Lopes

Joaquim Roberto Costa Lopes

Jean Pierre Barguil Brasileiro

Ingrid de Oliveira

Ricardo Peclat Lacerda

Marcos Renato Dib Andrade

Natalia Ivet Zavattiero Tierno

Roberto Costa Cavalcante de Souza

Luiz Augusto Casulari Roxo da Motta

Affiliations

Soon will be listed here.

Abstract

Objective: Vitamin D has several metabolic functions and possible reproductive functions. This study aimed to determine the prevalence of vitamin D deficiency among Brazilian women of reproductive age, and to evaluate the relationship between serum 25-hydroxyvitamin D [25(OH)D] concentrations and infertility causes.

Subjects And Methods: This retrospective cross-sectional study evaluated data from a private Brazilian assisted reproduction center that were collected between January 1 and May 5, 2012. Serum 25(OH)D concentrations were measured and compared for infertile and fertile women. Concentrations of 25(OH)D that were < 20 ng/mL were defined as deficiency and concentrations of 21-30 ng/mL were defined as hypovitaminosis D.

Results: Among the 369 evaluated women, 81.1% exhibited hypovitaminosis D and 32.0% exhibited deficiency. The infertile and control patients did not exhibit any significant differences in the prevalence of vitamin D deficiency (30.2% vs. 35%, respectively; p = 0.33) or in the mean 25(OH)D concentrations (24.3 ± 7.9 ng/mL vs. 23.8 ± 8.7 ng/mL, respectively; p = 0.51). Furthermore, there were no significant differences in the mean 25(OH)D concentrations among subgroups of patients with single infertility factors, or between these subgroups and the control group.

Conclusions: A high proportion of Brazilian women of reproductive age exhibited vitamin D deficiency, regardless of their fertility status. Thus, it may be useful to evaluate this population for vitamin D deficiency, although future studies are needed to determine whether this deficiency might affect the outcomes of treatments for infertility.

Citing Articles

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Vitamin D and Mitosis Evaluation in Endometriosis: A Step toward Discovering the Connection?.

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