Vitamin D Receptor Polymorphism Is Associated With Reduced Follicle Number in Women Utilizing Assisted Reproductive Technologies

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2018 Jun 13

PMID 29892263

Citations 5

Authors

Mila W Reginatto

Bartira M Pizarro

Roberto A Antunes

Ana C A Mancebo

Luisa Hoffmann

Pamela Fernandes

Patricia Areas

Maria I Chiamolera

Rosane Silva

Maria do Carmo Borges de Souza

Enrrico Bloise

Tania M Ortiga-Carvalho

Affiliations

Soon will be listed here.

Abstract

Purpose: Calcitriol, or 1,25-hydroxycholecalciferol, is the active form of vitamin D. It binds and activates vitamin D receptor (VDR). Infertility and defective folliculogenesis have been observed in female knockout mice; however, whether polymorphisms affect human ovarian responses to controlled ovarian stimulation (COS) remains unclear. We hypothesized that polymorphisms are associated with infertility and COS responses. Thus, we evaluated the association between the , and polymorphisms and ovarian responses in women undergoing COS.

Methods: In this study, we recruited a control group ( = 121) comprising volunteers with a history of natural conception and a second group of women undergoing COS ( = 70). , and genotyping was performed restriction fragment length polymorphism analysis or TaqMan qPCR and Sanger sequencing. Intrafollicular 25(OH)D contents were measured in follicular fluid collected from COS patients during oocyte retrieval. Ovarian response parameters were obtained from patient medical records.

Results: There were no significant differences in the genotype frequencies of polymorphisms ( and between the control and COS groups. However, the allele frequency of (C allele) was significantly lower in the COS group than in the control group ( = 0.02). Follicle number but not oocyte number was lower in patients with polymorphic (TC/CC) genotypes ( = 0.03). Importantly, the ratio between the number of follicles retrieved and intrafollicular estradiol concentrations was higher in patients with the TC/CC genotypes ( < 0.02).

Conclusion: We identified an association between the polymorphism and reduced follicle number in women undergoing COS, suggesting that signaling affects the ovarian response to stimulation unknown mechanisms.

Citing Articles

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Association of vitamin D receptor genetic polymorphisms with the risk of infertility: a systematic review and meta-analysis.

Moradkhani A, Azami M, Assadi S, Ghaderi M, Azarnezhad A, Moradi Y BMC Pregnancy Childbirth. 2024; 24(1):398.

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Esencan E, Beroukhim G, Seifer D Reprod Biol Endocrinol. 2022; 20(1):156.

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Vitamin D in follicular development and oocyte maturation.

Xu F, Wolf S, Green O, Xu J Reproduction. 2021; 161(6):R129-R137.

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Estradiol and Progesterone Levels are Related to Redox Status in the Follicular Fluid During Fertilization.

Pizarro B, Cordeiro A, Reginatto M, Campos S, Mancebo A, Areas P J Endocr Soc. 2020; 4(7):bvaa064.

PMID: 32666010 PMC: 7326473. DOI: 10.1210/jendso/bvaa064.

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