CXCL9: Evidence and Contradictions for Its Role in Tumor Progression

Overview

Journal Cancer Med

Specialty Oncology

Date 2016 Oct 12

PMID 27726306

Citations 78

Authors

Qiang Ding

Panpan Lu

Yujia Xia

Shuping Ding

Yuhui Fan

Xin Li

Ping Han

Jingmei Liu

Dean Tian

Mei Liu

Affiliations

Soon will be listed here.

Abstract

Chemokines are a group of low molecular weight peptides. Their major function is the recruitment of leukocytes to inflammation sites, but they also play a key role in tumor growth, angiogenesis, and metastasis. In the last few years, accumulated experimental evidence supports that monokine induced by interferon (IFN)-gamma (CXCL9), a member of CXC chemokine family and known to attract CXCR3- (CXCR3-A and CXCR3-B) T lymphocytes, is involved in the pathogenesis of a variety of physiologic diseases during their initiation and their maintenance. This review for the first time presents the most comprehensive summary for the role of CXCL9 in different types of tumors, and demonstrates its contradictory role of CXCL9 in tumor progression. Altogether, this is a useful resource for researchers investigating therapeutic opportunities for cancer.

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