Downregulation of ARHGDIA Contributes to Human Glioma Progression Through Activation of Rho GTPase Signaling Pathway

Overview

Journal Tumour Biol

Publisher Sage Publications

Specialty Oncology

Date 2016 Oct 12

PMID 27726098

Citations 11

Authors

Weiliang Lu

Xixi Wang

Jingjing Liu

Yu He

Ziwei Liang

Zijing Xia

Ying Cai

Liangxue Zhou

Hongxia Zhu

Shufang Liang

Affiliations

Soon will be listed here.

Abstract

The protein ARHGDIA has been found to play distinct roles in cancer progression for several tumors. However, it remains elusive whether and how ARHGDIA plays functions in human glioma. In this study, we discovered that ARHGDIA is much downregulated in human glioma; meanwhile, its expression negatively correlates with glioma malignancy and positively relates to prognosis of glioma patients. It has independent predictive value of ARHGDIA expression level for overall survival of human glioma patients. Glioma patients with ARHGDIA-positive expression have a longer overall survival time than ARHGDIA-negative patients. Knockdown of ARHGDIA promotes cell proliferation, cell cycle progression, and cell migration due to the activation of Rho GTPases (Rac1, Cdc42, and RhoA) and Akt phosphorylation, whereas overexpression of ARHGDIA suppresses cell growth, cell cycle progression, and cell migration. ARHGDIA is a potential prognostic marker and therapeutic target for human glioma.

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References

Harding M, Theodorescu D . RhoGDI signaling provides targets for cancer therapy. Eur J Cancer. 2010; 46(7):1252-9. PMC: 11207191. DOI: 10.1016/j.ejca.2010.02.025. View

Reyes S, Narayanan A, Lee H, Tchaicha J, Aldape K, Lang F . αvβ8 integrin interacts with RhoGDI1 to regulate Rac1 and Cdc42 activation and drive glioblastoma cell invasion. Mol Biol Cell. 2013; 24(4):474-82. PMC: 3571870. DOI: 10.1091/mbc.E12-07-0521. View

Ponomarev I, Wang S, Zhang L, Harris R, Mayfield R . Gene coexpression networks in human brain identify epigenetic modifications in alcohol dependence. J Neurosci. 2012; 32(5):1884-97. PMC: 3564514. DOI: 10.1523/JNEUROSCI.3136-11.2012. View

Goldberg L, Kloog Y . A Ras inhibitor tilts the balance between Rac and Rho and blocks phosphatidylinositol 3-kinase-dependent glioblastoma cell migration. Cancer Res. 2006; 66(24):11709-17. DOI: 10.1158/0008-5472.CAN-06-1878. View

Jiang W, Watkins G, Lane J, Cunnick G, Douglas-Jones A, Mokbel K . Prognostic value of rho GTPases and rho guanine nucleotide dissociation inhibitors in human breast cancers. Clin Cancer Res. 2003; 9(17):6432-40. View

Jones M, Krutzsch H, Shu H, Zhao Y, Liotta L, Kohn E . Proteomic analysis and identification of new biomarkers and therapeutic targets for invasive ovarian cancer. Proteomics. 2002; 2(1):76-84. View

Jin X, Liu Y, Liu J, Lu W, Liang Z, Zhang D . The Overexpression of IQGAP1 and β-Catenin Is Associated with Tumor Progression in Hepatocellular Carcinoma In Vitro and In Vivo. PLoS One. 2015; 10(8):e0133770. PMC: 4529304. DOI: 10.1371/journal.pone.0133770. View

Cherfils J, Zeghouf M . Regulation of small GTPases by GEFs, GAPs, and GDIs. Physiol Rev. 2013; 93(1):269-309. DOI: 10.1152/physrev.00003.2012. View

Hoffman G, Nassar N, Cerione R . Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI. Cell. 2000; 100(3):345-56. DOI: 10.1016/s0092-8674(00)80670-4. View

10.

Wen P, Kesari S . Malignant gliomas in adults. N Engl J Med. 2008; 359(5):492-507. DOI: 10.1056/NEJMra0708126. View

11.

Liang L, Li Q, Huang L, Li D, Wang Y, Li X . Loss of ARHGDIA expression is associated with poor prognosis in HCC and promotes invasion and metastasis of HCC cells. Int J Oncol. 2014; 45(2):659-66. DOI: 10.3892/ijo.2014.2451. View

12.

Turner S, Zhuang S, Zhang T, Boss G, Pilz R . Effects of lovastatin on Rho isoform expression, activity, and association with guanine nucleotide dissociation inhibitors. Biochem Pharmacol. 2007; 75(2):405-13. PMC: 2228324. DOI: 10.1016/j.bcp.2007.08.031. View

13.

Louis D, Ohgaki H, Wiestler O, Cavenee W, Burger P, Jouvet A . The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007; 114(2):97-109. PMC: 1929165. DOI: 10.1007/s00401-007-0243-4. View

14.

Shibata S, Nagase M, Yoshida S, Kawarazaki W, Kurihara H, Tanaka H . Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease. Nat Med. 2008; 14(12):1370-6. DOI: 10.1038/nm.1879. View

15.

Liang S, Xu Y, Shen G, Zhao X, Zhou J, Li X . Gene expression and methylation status of 14-3-3sigma in human renal carcinoma tissues. IUBMB Life. 2008; 60(8):534-40. DOI: 10.1002/iub.75. View

16.

Zhang L, Yin A, Cheng J, Huang H, Li X, Zhang Y . TRIM24 promotes glioma progression and enhances chemoresistance through activation of the PI3K/Akt signaling pathway. Oncogene. 2014; 34(5):600-10. DOI: 10.1038/onc.2013.593. View

17.

Zhao L, Wang H, Sun X, Ding Y . Comparative proteomic analysis identifies proteins associated with the development and progression of colorectal carcinoma. FEBS J. 2010; 277(20):4195-204. DOI: 10.1111/j.1742-4658.2010.07808.x. View

18.

Wei L, Imanaka-Yoshida K, Wang L, Zhan S, Schneider M, DeMayo F . Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation. Development. 2002; 129(7):1705-14. DOI: 10.1242/dev.129.7.1705. View

19.

Ostrom Q, Gittleman H, Farah P, Ondracek A, Chen Y, Wolinsky Y . CBTRUS statistical report: Primary brain and central nervous system tumors diagnosed in the United States in 2006-2010. Neuro Oncol. 2013; 15 Suppl 2:ii1-56. PMC: 3798196. DOI: 10.1093/neuonc/not151. View

20.

Lee H, Cheerathodi M, Chaki S, Reyes S, Zheng Y, Lu Z . Protein tyrosine phosphatase-PEST and β8 integrin regulate spatiotemporal patterns of RhoGDI1 activation in migrating cells. Mol Cell Biol. 2015; 35(8):1401-13. PMC: 4372704. DOI: 10.1128/MCB.00112-15. View