RhoGDI Signaling Provides Targets for Cancer Therapy

Overview

Journal Eur J Cancer

Specialty Oncology

Date 2010 Mar 30

PMID 20347589

Citations 48

Authors

Michael A Harding

Dan Theodorescu

Affiliations

Soon will be listed here.

Abstract

Rho GDP-Dissociation Inhibitors (RhoGDIs) are important regulators of the Rho family of small GTPases. The expression of RhoGDIs is altered in a variety of cancers and they have been shown to mediate several processes during tumorigenesis and cancer progression. Using examples of RhoGDI-mediated signaling and expression patterns in endothelial cells as well as pancreatic, breast, and bladder cancer, the multitude of potential cancer therapeutic targets presented by a better understanding of their function is illustrated. Several novel therapeutic strategies are proposed for intervening in RhoGDI signaling, and potential complications arising from their implementation are discussed.

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