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Some Factors Affecting the Specific Toxicity of Misonidazole Towards Hypoxic Mammalian Cells

Overview
Journal Br J Cancer Suppl
Specialty Oncology
Date 1978 Jun 1
PMID 277212
Citations 7
Authors
I J Stratford
P Gray
Affiliations
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Abstract

The toxic action of misonidazole towards hypoxic mammalian cells has been shown to be a function of serum concentration, with higher serum concentrations enhancing the toxic effect. Added thiols protect cells against misonidazole toxicity. In addition, the action of misonidazole on hypoxic cells labelled with 5-BUdR has been examined. Cells with incroported 5-BUdR are no more sensitive to misonidazole toxicity than are cells without label.

Citing Articles

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Mitochondrial alterations produced by misonidazole: a study using Amoeba proteus as a single-cell model.

Smith R Br J Cancer. 1980; 41(2):305-8.

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Enhancement of the cytotoxicity of radiosensitizers by modest hyperthermia: the electron-affinity relationship.

Rajaratnam S, Adams G, Stratford I, Clarke C Br J Cancer. 1982; 46(6):912-7.

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Enhancing effect of pre-treatment of cells with misonidazole in hypoxia on their response to melphalan in air.

Smith E, Stratford I, Adams G Br J Cancer. 1982; 46(1):117-26.

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Low concentrations of misonidazole counteract effects of extreme hypoxia on cells in S.

Pettersen E, Lindmo T Br J Cancer. 1981; 43(3):355-66.

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