Acquired Hypofibrinogenemia: Current Perspectives

Overview

Journal J Blood Med

Publisher Dove Medical Press

Specialty Hematology

Date 2016 Oct 8

PMID 27713652

Citations 21

Authors

Martin W Besser

Stephen G MacDonald

Affiliations

Soon will be listed here.

Abstract

Acquired hypofibrinogenemia is most frequently caused by hemodilution and consumption of clotting factors. The aggressive replacement of fibrinogen has become one of the core principles of modern management of massive hemorrhage. The best method for determining the patient's fibrinogen level remains controversial, and particularly in acquired dysfibrinogenemia, could have major therapeutic implications depending on which quantification method is chosen. This review introduces the available laboratory and point-of-care methods and discusses the relative advantages and limitations. It also discusses current strategies for the correction of hypofibrinogenemia.

Citing Articles

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Gomes M, Angelo-Dias M, Lima J J Clin Med. 2024; 13(19).

PMID: 39408077 PMC: 11477569. DOI: 10.3390/jcm13196018.

Highly thrombogenic phenotype and impaired wound healing in a patient with congenital dysfibrinogenemia: case report.

El Beayni N, Szanto T, Neerman-Arbez M, Casini A, Lassila R Res Pract Thromb Haemost. 2024; 8(4):102469.

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Safety of Fibrinogen Concentrate in Non-Trauma and Non-Obstetric Adult Patients during Perioperative Care: Systematic Review and Meta-Analysis.

Gomes M, Angelo-Dias M, Duarte G, Dias S, Serra S, Lima J J Clin Med. 2024; 13(12).

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[Pathophysiology, diagnosis, and therapy for the management of acquired clotting factor deficiency].

Yu D, Liu W, Zhang L Zhonghua Xue Ye Xue Za Zhi. 2024; 44(11):956-962.

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Ranking as a Procedure for Selecting a Replacement Variable in the Score Predicting the Survival of Patients Treated with Curative Intent for Colorectal Liver Metastases.

Plahuta I, Mencinger M, Perus I, Magdalenic T, Turk S, Brumec A Medicina (Kaunas). 2023; 59(11).

PMID: 38004052 PMC: 10673064. DOI: 10.3390/medicina59112003.

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