New Initiation Modes for Directed Carbonylative C-C Bond Activation: Rhodium-Catalyzed (3 + 1 + 2) Cycloadditions of Aminomethylcyclopropanes

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2016 Oct 7

PMID 27709913

Citations 9

Authors

Gang-Wei Wang

Niall G McCreanor

Megan H Shaw

William G Whittingham

John F Bower

Affiliations

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Abstract

Under carbonylative conditions, neutral Rh(I)-systems modified with weak donor ligands (AsPh or 1,4-oxathiane) undergo N-Cbz, N-benzoyl, or N-Ts directed insertion into the proximal C-C bond of aminomethylcyclopropanes to generate rhodacyclopentanone intermediates. These are trapped by N-tethered alkenes to provide complex perhydroisoindoles.

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