Nicotine Protects Against DSS Colitis Through Regulating MicroRNA-124 and STAT3

Overview

Journal J Mol Med (Berl)

Specialty General Medicine

Date 2016 Oct 7

PMID 27709266

Citations 26

Authors

Zhen Qin

Jing-Jing Wan

Yang Sun

Tingyu Wu

Peng-Yuan Wang

Peng Du

Ding-Feng Su

Yili Yang

Xia Liu

Affiliations

Soon will be listed here.

Abstract

Key Message: Nicotine upregulates miR-124 expression in ulcerative colon tissues and cells. MiR-124 is required for the protective role of nicotine in DSS colitis mice and epithelial cells. The protective effect of nicotine in murine DSS colitis depends on blocking STAT3 activation. MiR-124 mediates the inhibitory role of nicotine on STAT3/p-STAT3. Targeting miR-124 and STAT3 represents a novel approach for treating ulcerative colitis.

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