Nicotine Addiction

Overview

Journal N Engl J Med

Specialty General Medicine

Date 2010 Jun 18

PMID 20554984

Citations 648

Authors

Neal L Benowitz

Affiliations

Soon will be listed here.

Citing Articles

Investigating the effect of Arvcf reveals an essential role on regulating the mesolimbic dopamine signaling-mediated nicotine reward.

Wang Y, Yang Z, Shi X, Han H, Li A, Zhang B Commun Biol. 2025; 8(1):429.

PMID: 40082601 PMC: 11906728. DOI: 10.1038/s42003-025-07837-y.

Nicotine Exposure From Smoking Tobacco and Vaping Among Adolescents.

Hammond D, Reid J, Goniewicz M, McNeill A, OConnor R, Corsetti D JAMA Netw Open. 2025; 8(3):e2462544.

PMID: 40072439 PMC: 11904731. DOI: 10.1001/jamanetworkopen.2024.62544.

Pathway from Exposure to an E-Cigarette Prevention Social Media Campaign to Increased Quitting Intentions: A Randomized Trial Among Young Adult E-Cigarette Users.

DEsterre A, Tulsiani S, Hair E, Aseltine M, Yu L, Ichimiya M Int J Environ Res Public Health. 2025; 22(2).

PMID: 40003532 PMC: 11855058. DOI: 10.3390/ijerph22020307.

Acid Sphingomyelinase and Ceramide Signaling Pathway Mediates Nicotine-Induced NLRP3 Inflammasome Activation and Podocyte Injury.

Rahman M, Datta S, Lakkakula H, Koka S, Boini K Biomedicines. 2025; 13(2).

PMID: 40002829 PMC: 11852453. DOI: 10.3390/biomedicines13020416.

Metabolomic Insights into Smoking-Induced Metabolic Dysfunctions: A Comprehensive Analysis of Lipid and Amino Acid Metabolomes.

Aslam M, Iqbal H, Ilyas K, Rehman K, Hussain A, Akash M Metabolites. 2025; 15(2).

PMID: 39997721 PMC: 11857658. DOI: 10.3390/metabo15020096.

References

Pillai S, Ge D, Zhu G, Kong X, Shianna K, Need A . A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet. 2009; 5(3):e1000421. PMC: 2650282. DOI: 10.1371/journal.pgen.1000421. View

Olausson P, Jentsch J, Taylor J . Repeated nicotine exposure enhances responding with conditioned reinforcement. Psychopharmacology (Berl). 2004; 173(1-2):98-104. DOI: 10.1007/s00213-003-1702-9. View

Naqvi N, Rudrauf D, Damasio H, Bechara A . Damage to the insula disrupts addiction to cigarette smoking. Science. 2007; 315(5811):531-4. PMC: 3698854. DOI: 10.1126/science.1135926. View

Levin E, Bettegowda C, Blosser J, Gordon J . AR-R17779, and alpha7 nicotinic agonist, improves learning and memory in rats. Behav Pharmacol. 2000; 10(6-7):675-80. DOI: 10.1097/00008877-199911000-00014. View

Wonnacott S . Presynaptic nicotinic ACh receptors. Trends Neurosci. 1997; 20(2):92-8. DOI: 10.1016/s0166-2236(96)10073-4. View

Hughes J . Clinical significance of tobacco withdrawal. Nicotine Tob Res. 2006; 8(2):153-6. DOI: 10.1080/14622200500494856. View

Benowitz N . Cigarette smoking and nicotine addiction. Med Clin North Am. 1992; 76(2):415-37. DOI: 10.1016/s0025-7125(16)30360-1. View

Carpenter C, Wayne G, Connolly G . The role of sensory perception in the development and targeting of tobacco products. Addiction. 2007; 102(1):136-47. DOI: 10.1111/j.1360-0443.2006.01649.x. View

Dani J, Harris R . Nicotine addiction and comorbidity with alcohol abuse and mental illness. Nat Neurosci. 2005; 8(11):1465-70. DOI: 10.1038/nn1580. View

10.

Dajas-Bailador F, Wonnacott S . Nicotinic acetylcholine receptors and the regulation of neuronal signalling. Trends Pharmacol Sci. 2004; 25(6):317-24. DOI: 10.1016/j.tips.2004.04.006. View

11.

Mansvelder H, McGehee D . Long-term potentiation of excitatory inputs to brain reward areas by nicotine. Neuron. 2000; 27(2):349-57. DOI: 10.1016/s0896-6273(00)00042-8. View

12.

Le Marchand L, Derby K, Murphy S, Hecht S, Hatsukami D, Carmella S . Smokers with the CHRNA lung cancer-associated variants are exposed to higher levels of nicotine equivalents and a carcinogenic tobacco-specific nitrosamine. Cancer Res. 2008; 68(22):9137-40. PMC: 2587068. DOI: 10.1158/0008-5472.CAN-08-2271. View

13.

Samaha A, Yau W, Yang P, Robinson T . Rapid delivery of nicotine promotes behavioral sensitization and alters its neurobiological impact. Biol Psychiatry. 2005; 57(4):351-60. DOI: 10.1016/j.biopsych.2004.11.040. View

14.

Perkins K, Scott J . Sex differences in long-term smoking cessation rates due to nicotine patch. Nicotine Tob Res. 2008; 10(7):1245-50. DOI: 10.1080/14622200802097506. View

15.

Dwyer J, McQuown S, Leslie F . The dynamic effects of nicotine on the developing brain. Pharmacol Ther. 2009; 122(2):125-39. PMC: 2746456. DOI: 10.1016/j.pharmthera.2009.02.003. View

16.

Hung R, McKay J, Gaborieau V, Boffetta P, Hashibe M, Zaridze D . A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature. 2008; 452(7187):633-7. DOI: 10.1038/nature06885. View

17.

Knott V, Heenan A, Shah D, Bolton K, Fisher D, Villeneuve C . Electrophysiological evidence of nicotine's distracter-filtering properties in non-smokers. J Psychopharmacol. 2009; 25(2):239-48. DOI: 10.1177/0269881109348158. View

18.

Kalman D, Morissette S, George T . Co-morbidity of smoking in patients with psychiatric and substance use disorders. Am J Addict. 2005; 14(2):106-23. PMC: 1199553. DOI: 10.1080/10550490590924728. View

19.

Brody A . Functional brain imaging of tobacco use and dependence. J Psychiatr Res. 2005; 40(5):404-18. PMC: 2876087. DOI: 10.1016/j.jpsychires.2005.04.012. View

20.

Ziedonis D, Hitsman B, Beckham J, Zvolensky M, Adler L, Audrain-McGovern J . Tobacco use and cessation in psychiatric disorders: National Institute of Mental Health report. Nicotine Tob Res. 2008; 10(12):1691-715. DOI: 10.1080/14622200802443569. View