New Concepts on Pathogenesis and Diagnosis of Liver Fibrosis; A Review Article

Overview

Journal Middle East J Dig Dis

Specialty Gastroenterology

Date 2016 Oct 5

PMID 27698966

Citations 16

Authors

Hedyeh Ebrahimi

Mohammadreza Naderian

Amir Ali Sohrabpour

Affiliations

Soon will be listed here.

Abstract

Liver fibrosis is a potentially reversible response to hepatic insults, triggered by different chronic diseases most importantly viral hepatitis, alcoholic, and nonalcoholic fatty liver disease. In the course of the chronic liver disease, hepatic fibrogenesis may develop, which is attributed to various types of cells, molecules, and pathways. Activated hepatic stellate cell (HSC), the primary source of extracellular matrix (ECM), is fundamental in pathophysiology of fibrogenesis, and thus is the most attractable target for reversing liver fibrosis. Although, liver biopsy has long been considered as the gold standard for diagnosis and staging of hepatic fibrosis, assessing progression and regression by biopsy is hampered by its limitations. We provide recent views on noninvasive approaches including serum biomarkers and radiologic techniques.

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