Liver Fibrosis: a Compilation on the Biomarkers Status and Their Significance During Disease Progression

Overview

Journal Future Sci OA

Specialty Biotechnology

Date 2017 Dec 20

PMID 29255622

Citations 64

Authors

Krishna Sumanth Nallagangula

Shashidhar Kurpad Nagaraj

Lakshmaiah Venkataswamy

Muninarayana Chandrappa

Affiliations

Soon will be listed here.

Abstract

Liver fibrosis occurs in response to different etiologies of chronic liver injury. Diagnosing degree of liver fibrosis is a crucial step in evaluation of severity of the disease. An invasive liver biopsy is the gold standard method associated with pain and complications. Biomarkers to detect liver fibrosis include direct markers of extracellular matrix turnover and indirect markers as a reflection of liver dysfunction. Although a single marker may not be useful for successful management, a mathematical equation combining tests might be effective. The main purpose of this review is to understand the diagnostic accuracy of biomarkers and scoring systems for liver fibrosis. Advances in -omics approach have generated clinically significant biomarker candidates for liver fibrosis that need further evaluation.

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