Sleep Characteristics in Type 1 Diabetes and Associations with Glycemic Control: Systematic Review and Meta-analysis

Overview

Journal Sleep Med

Specialties Neurology
Psychiatry

Date 2016 Oct 4

PMID 27692274

Citations 89

Authors

Sirimon Reutrakul

Ammarin Thakkinstian

Thunyarat Anothaisintawee

Sasipas Chontong

Anne-Laure Borel

Michelle M Perfect

Carolina Castro Porto Silva Janovsky

Romain Kessler

Bernd Schultes

Igor Alexander Harsch

Marieke van Dijk

Didier Bouhassira

Bartlomiej Matejko

Rebecca B Lipton

Parawee Suwannalai

Naricha Chirakalwasan

Anne-Katrin Schober

Kristen L Knutson

Affiliations

Soon will be listed here.

Abstract

Objectives: The association between inadequate sleep and type 2 diabetes has garnered much attention, but little is known about sleep and type 1 diabetes (T1D). Our objectives were to conduct a systematic review and meta-analysis comparing sleep in persons with and without T1D, and to explore relationships between sleep and glycemic control in T1D.

Methods: Studies were identified from Medline and Scopus. Studies reporting measures of sleep in T1D patients and controls, and/or associations between sleep and glycemic control, were selected.

Results: A total of 22 studies were eligible for the meta-analysis. Children with T1D had shorter sleep duration (mean difference [MD] = -26.4 minutes; 95% confidence interval [CI] = -35.4, -17.7) than controls. Adults with T1D reported poorer sleep quality (MD in standardized sleep quality score = 0.51; 95% CI = 0.33, 0.70), with higher scores reflecting worse sleep quality) than controls, but there was no difference in self-reported sleep duration. Adults with TID who reported sleeping >6 hours had lower hemoglobin A1c (HbA1c) levels than those sleeping ≤6 hours (MD = -0.24%; 95% CI = -0.47, -0.02), and participants reporting good sleep quality had lower HbA1c than those with poor sleep quality (MD = -0.19%; 95% CI = -0.30, -0.08). The estimated prevalence of obstructive sleep apnea (OSA) in adults with TID was 51.9% (95% CI = 31.2, 72.6). Patients with moderate-to-severe OSA had a trend toward higher HbA1c (MD = 0.39%, 95% CI = -0.08, 0.87).

Conclusion: T1D was associated with poorer sleep and high prevalence of OSA. Poor sleep quality, shorter sleep duration, and OSA were associated with suboptimal glycemic control in T1D patients.

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