Nanosized Drug Delivery Systems in Gastrointestinal Targeting: Interactions with Microbiota

Overview

Journal Pharmaceuticals (Basel)

Publisher MDPI

Specialty Chemistry

Date 2016 Oct 1

PMID 27690060

Citations 11

Authors

Michail Karavolos

Alina Holban

Affiliations

Soon will be listed here.

Abstract

The new age of nanotechnology has signaled a stream of entrepreneurial possibilities in various areas, form industry to medicine. Drug delivery has benefited the most by introducing nanostructured systems in the transport and controlled release of therapeutic molecules at targeted sites associated with a particular disease. As many nanosized particles reach the gastrointestinal tract by various means, their interactions with the molecular components of this highly active niche are intensively investigated. The well-characterized antimicrobial activities of numerous nanoparticles are currently being considered as a reliable and efficient alternative to the eminent world crisis in antimicrobial drug discovery. The interactions of nanosystems present in the gastrointestinal route with host microbiota is unavoidable; hence, a major research initiative is needed to explore the mechanisms and effects of these nanomaterials on microbiota and the impact that microbiota may have in the outcome of therapies entailing drug delivery nanosystems through the gastrointestinal route. These coordinated studies will provide novel techniques to replace or act synergistically with current technologies and help develop new treatments for major diseases via the discovery of unique antimicrobial molecules.

Citing Articles

Boosting nanotoxicity to combat multidrug-resistant bacteria in pathophysiological environments.

Westmeier D, Siemer S, Vallet C, Steinmann J, Docter D, Buer J Nanoscale Adv. 2022; 2(11):5428-5440.

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Modulation of Gut Microbiota by Essential Oils and Inorganic Nanoparticles: Impact in Nutrition and Health.

Lazar V, Holban A, Curutiu C, Ditu L Front Nutr. 2022; 9:920413.

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Microfluidic Synthesis and Purification of Magnetoliposomes for Potential Applications in the Gastrointestinal Delivery of Difficult-to-Transport Drugs.

Torres C, Cifuentes J, Gomez S, Quezada V, Giraldo K, Puentes P Pharmaceutics. 2022; 14(2).

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Nanotechnologies in Food Science: Applications, Recent Trends, and Future Perspectives.

Nile S, Baskar V, Selvaraj D, Nile A, Xiao J, Kai G Nanomicro Lett. 2021; 12(1):45.

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Current approaches in lipid-based nanocarriers for oral drug delivery.

Plaza-Oliver M, Santander-Ortega M, Lozano M Drug Deliv Transl Res. 2021; 11(2):471-497.

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