Fluorescence-guided Surgery of a Highly-metastatic Variant of Human Triple-negative Breast Cancer Targeted with a Cancer-specific GFP Adenovirus Prevents Recurrence

Overview

Journal Oncotarget

Specialty Oncology

Date 2016 Oct 1

PMID 27689331

Citations 13

Authors

Shuya Yano

Kiyoto Takehara

Shinji Miwa

Hiroyuki Kishimoto

Hiroshi Tazawa

Yasuo Urata

Shunsuke Kagawa

Michael Bouvet

Toshiyoshi Fujiwara

Robert M Hoffman

Affiliations

Soon will be listed here.

Abstract

We have previously developed a genetically-engineered GFP-expressing telomerase-dependent adenovirus, OBP-401, which can selectively illuminate cancer cells. In the present report, we demonstrate that targeting a triple-negative high-invasive human breast cancer, orthotopically-growing in nude mice, with OBP-401 enables curative fluorescence-guided surgery (FGS). OBP-401 enabled complete resection and prevented local recurrence and greatly inhibited lymph-node metastasis due to the ability of the virus to selectively label and subsequently kill cancer cells. In contrast, residual breast cancer cells become more aggressive after bright (white)-light surgery (BLS). OBP-401-based FGS also improved the overall survival compared with conventional BLS. Thus, metastasis from a highly-aggressive triple-negative breast cancer can be prevented by FGS in a clinically-relevant mouse model.

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