Genomic and Functional Analysis of the Host Response to Acute Simian Varicella Infection in the Lung

Overview

Journal Sci Rep

Specialty Science

Date 2016 Sep 29

PMID 27677639

Citations 10

Authors

Nicole Arnold

Thomas Girke

Suhas Sureshchandra

Christina Nguyen

Maham Rais

Ilhem Messaoudi

Affiliations

Soon will be listed here.

Abstract

Varicella Zoster Virus (VZV) is the causative agent of varicella and herpes zoster. Although it is well established that VZV is transmitted via the respiratory route, the host-pathogen interactions during acute VZV infection in the lungs remain poorly understood due to limited access to clinical samples. To address these gaps in our knowledge, we leveraged a nonhuman primate model of VZV infection where rhesus macaques are intrabronchially challenged with the closely related Simian Varicella Virus (SVV). Acute infection is characterized by immune infiltration of the lung airways, a significant up-regulation of genes involved in antiviral-immunity, and a down-regulation of genes involved in lung development. This is followed by a decrease in viral loads and increased expression of genes associated with cell cycle and tissue repair. These data provide the first characterization of the host response required to control varicella virus replication in the lung and provide insight into mechanisms by which VZV infection can cause lung injury in an immune competent host.

Citing Articles

Transcriptional and functional remodeling of lung-resident T cells and macrophages by Simian varicella virus infection.

Doratt B, Malherbe D, Messaoudi I Front Immunol. 2024; 15:1408212.

PMID: 38887303 PMC: 11180879. DOI: 10.3389/fimmu.2024.1408212.

Humanized Severe Combined Immunodeficient (SCID) Mouse Models for Varicella-Zoster Virus Pathogenesis.

Lloyd M, Moffat J Curr Top Microbiol Immunol. 2022; 438:135-161.

PMID: 35292858 DOI: 10.1007/82_2022_255.

Simian Varicella Virus: Molecular Virology and Mechanisms of Pathogenesis.

Jankeel A, Coimbra-Ibraim I, Messaoudi I Curr Top Microbiol Immunol. 2021; 438:163-188.

PMID: 34669041 PMC: 9577235. DOI: 10.1007/82_2021_241.

Viral Respiratory Pathogens and Lung Injury.

Clementi N, Ghosh S, De Santis M, Castelli M, Criscuolo E, Zanoni I Clin Microbiol Rev. 2021; 34(3).

PMID: 33789928 PMC: 8142519. DOI: 10.1128/CMR.00103-20.

Alveolar barrier disruption in varicella pneumonia is associated with neutrophil extracellular trap formation.

Ouwendijk W, van den Ham H, Delany M, van Kampen J, van Nierop G, Mehraban T JCI Insight. 2020; 5(21).

PMID: 33021967 PMC: 7710321. DOI: 10.1172/jci.insight.138900.

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