Single-Cell Approaches: Pandora's Box of Developmental Mechanisms
Overview
Reproductive Medicine
Affiliations
Single-cell approaches are providing a new lexicon of developmental cell biology by revealing heterogeneities in seemingly uniform cellular populations. By bridging scales, single-cell approaches should, in principle, galvanize our understanding of how individual cells adopt distinct fates as they build complex tissues.
A Notch between vascular morphogenesis and transcriptional identity.
Gomez-Salinero J, Rafii S Nat Cardiovasc Res. 2024; 2(6):492-493.
PMID: 39195888 DOI: 10.1038/s44161-023-00282-2.
scPCOR-seq enables co-profiling of chromatin occupancy and RNAs in single cells.
Pan L, Ku W, Tang Q, Cao Y, Zhao K Commun Biol. 2022; 5(1):678.
PMID: 35804086 PMC: 9270334. DOI: 10.1038/s42003-022-03584-6.
The Impact of Heterogeneity on Single-Cell Sequencing.
Goldman S, MacKay M, Afshinnekoo E, Melnick A, Wu S, Mason C Front Genet. 2019; 10:8.
PMID: 30881372 PMC: 6405636. DOI: 10.3389/fgene.2019.00008.
Maps of variability in cell lineage trees.
Hicks D, Speed T, Yassin M, Russell S PLoS Comput Biol. 2019; 15(2):e1006745.
PMID: 30753182 PMC: 6388934. DOI: 10.1371/journal.pcbi.1006745.
Using single-cell genomics to understand developmental processes and cell fate decisions.
Griffiths J, Scialdone A, Marioni J Mol Syst Biol. 2018; 14(4):e8046.
PMID: 29661792 PMC: 5900446. DOI: 10.15252/msb.20178046.