Natural Compounds As Regulators of NLRP3 Inflammasome-Mediated IL-1 Production

Overview

Journal Mediators Inflamm

Publisher Wiley

Specialties Biochemistry
Pathology

Date 2016 Sep 28

PMID 27672241

Citations 54

Authors

Jozsef Tozser

Szilvia Benko

Affiliations

Soon will be listed here.

Abstract

IL-1 is one of the main proinflammatory cytokines that regulates a broad range of immune responses and also participates in several physiological processes. The canonical production of IL-1 requires multiprotein complexes called inflammasomes. One of the most intensively studied inflammasome complexes is the NLRP3 inflammasome. Its activation requires two signals: one signal "primes" the cells and induces the expression of NLRP3 and pro-IL-1, while the other signal leads to the assembly and activation of the complex. Several stimuli were reported to function as the second signal including reactive oxygen species, lysosomal rupture, or cytosolic ion perturbation. Despite very intensive studies, the precise function and regulation of the NLRP3 inflammasome are still not clear. However, many chronic inflammatory diseases are related to the overproduction of IL-1 that is mediated the NLRP3 inflammasome. In this review, we aimed to provide an overview of studies that demonstrated the effect of plant-derived natural compounds on NLRP3 inflammasome-mediated IL-1 production. Although many of these studies lack the mechanistic explanation of their action, these compounds may be considered as complementary supplements in the treatment of chronic inflammatory diseases, consumed as preventive agents, and may also be considered as molecular tools to study NLRP3 function.

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References

Meng G, Zhang F, Fuss I, Kitani A, Strober W . A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses. Immunity. 2009; 30(6):860-74. PMC: 2764254. DOI: 10.1016/j.immuni.2009.04.012. View

Pan C, Pan Z, Hu J, Chen W, Zhou G, Lin W . Mangiferin alleviates lipopolysaccharide and D-galactosamine-induced acute liver injury by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation. Eur J Pharmacol. 2015; 770:85-91. DOI: 10.1016/j.ejphar.2015.12.006. View

Rajanbabu V, Galam L, Fukumoto J, Enciso J, Tadikonda P, Lane T . Genipin suppresses NLRP3 inflammasome activation through uncoupling protein-2. Cell Immunol. 2015; 297(1):40-5. PMC: 4556539. DOI: 10.1016/j.cellimm.2015.06.002. View

Dunn J, Alvarez L, Zhang X, Soldati T . Reactive oxygen species and mitochondria: A nexus of cellular homeostasis. Redox Biol. 2015; 6:472-485. PMC: 4596921. DOI: 10.1016/j.redox.2015.09.005. View

Hooper P, Hooper P, Tytell M, Vigh L . Xenohormesis: health benefits from an eon of plant stress response evolution. Cell Stress Chaperones. 2010; 15(6):761-70. PMC: 3024065. DOI: 10.1007/s12192-010-0206-x. View

Lu J, Yao Q, Chen C . Ginseng compounds: an update on their molecular mechanisms and medical applications. Curr Vasc Pharmacol. 2009; 7(3):293-302. PMC: 2928028. DOI: 10.2174/157016109788340767. View

Han J, Shim D, Shin W, Heo K, Kwak S, Sim E . Anti-inflammatory effect of emodin via attenuation of NLRP3 inflammasome activation. Int J Mol Sci. 2015; 16(4):8102-9. PMC: 4425069. DOI: 10.3390/ijms16048102. View

Man S, Kanneganti T . Regulation of inflammasome activation. Immunol Rev. 2015; 265(1):6-21. PMC: 4400844. DOI: 10.1111/imr.12296. View

Howitz K, Sinclair D . Xenohormesis: sensing the chemical cues of other species. Cell. 2008; 133(3):387-91. PMC: 2504011. DOI: 10.1016/j.cell.2008.04.019. View

10.

Pulido-Moran M, Moreno-Fernandez J, Ramirez-Tortosa C, Ramirez-Tortosa M . Curcumin and Health. Molecules. 2016; 21(3):264. PMC: 6273481. DOI: 10.3390/molecules21030264. View

11.

Wu J, Xu X, Li Y, Kou J, Huang F, Liu B . Quercetin, luteolin and epigallocatechin gallate alleviate TXNIP and NLRP3-mediated inflammation and apoptosis with regulation of AMPK in endothelial cells. Eur J Pharmacol. 2014; 745:59-68. DOI: 10.1016/j.ejphar.2014.09.046. View

12.

Inoue H, Nakata R . Resveratrol Targets in Inflammation. Endocr Metab Immune Disord Drug Targets. 2015; 15(3):186-95. DOI: 10.2174/1871530315666150316120316. View

13.

Gabay E, Wolf G, Shavit Y, Yirmiya R, Tal M . Chronic blockade of interleukin-1 (IL-1) prevents and attenuates neuropathic pain behavior and spontaneous ectopic neuronal activity following nerve injury. Eur J Pain. 2010; 15(3):242-8. DOI: 10.1016/j.ejpain.2010.07.012. View

14.

Kim S, Joe Y, Jeong S, Zheng M, Back S, Park S . Endoplasmic reticulum stress is sufficient for the induction of IL-1β production via activation of the NF-κB and inflammasome pathways. Innate Immun. 2013; 20(8):799-815. DOI: 10.1177/1753425913508593. View

15.

Yang G, Lee H, Lee J . A pharmacological inhibitor of NLRP3 inflammasome prevents non-alcoholic fatty liver disease in a mouse model induced by high fat diet. Sci Rep. 2016; 6:24399. PMC: 4830938. DOI: 10.1038/srep24399. View

16.

Greaney A, Leppla S, Moayeri M . Bacterial Exotoxins and the Inflammasome. Front Immunol. 2015; 6:570. PMC: 4639612. DOI: 10.3389/fimmu.2015.00570. View

17.

Wang C, Pan Y, Zhang Q, Wang F, Kong L . Quercetin and allopurinol ameliorate kidney injury in STZ-treated rats with regulation of renal NLRP3 inflammasome activation and lipid accumulation. PLoS One. 2012; 7(6):e38285. PMC: 3372527. DOI: 10.1371/journal.pone.0038285. View

18.

Yu S, Du C, Chen W, Lei Q, Li N, Qi S . Genipin inhibits NLRP3 and NLRC4 inflammasome activation via autophagy suppression. Sci Rep. 2015; 5:17935. PMC: 4675967. DOI: 10.1038/srep17935. View

19.

Pazar B, Ea H, Narayan S, Kolly L, Bagnoud N, Chobaz V . Basic calcium phosphate crystals induce monocyte/macrophage IL-1β secretion through the NLRP3 inflammasome in vitro. J Immunol. 2011; 186(4):2495-502. DOI: 10.4049/jimmunol.1001284. View

20.

Elliott E, Sutterwala F . Initiation and perpetuation of NLRP3 inflammasome activation and assembly. Immunol Rev. 2015; 265(1):35-52. PMC: 4400874. DOI: 10.1111/imr.12286. View