Glycosylation and Stem Cells: Regulatory Roles and Application of IPSCs in the Study of Glycosylation-related Disorders

Overview

Journal Bioessays

Publisher Wiley

Specialties Biology
Cell Biology
Molecular Biology

Date 2016 Sep 27

PMID 27667795

Citations 13

Authors

Ryan P Berger

Michelle Dookwah

Richard Steet

Stephen Dalton

Affiliations

Soon will be listed here.

Abstract

Glycosylation refers to the co- and post-translational modification of protein and lipids by monosaccharides or oligosaccharide chains. The surface of mammalian cells is decorated by a heterogeneous and highly complex array of protein and lipid linked glycan structures that vary significantly between different cell types, raising questions about their roles in development and disease pathogenesis. This review will begin by focusing on recent findings that define roles for cell surface protein and lipid glycosylation in pluripotent stem cells and their functional impact during normal development. Then, we will describe how patient derived induced pluripotent stem cells are being used to model human diseases such as congenital disorders of glycosylation. Collectively, these studies indicate that cell surface glycans perform critical roles in human development and disease.

Citing Articles

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Mass Spectrometry Strategies for -Glycoproteomics.

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N-Linked Glycosylation in Chinese Hamster Ovary Cells Is Critical for Insulin-like Growth Factor 1 Signaling.

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Emerging roles of N-linked glycosylation in brain physiology and disorders.

Conroy L, Hawkinson T, Young L, Gentry M, Sun R Trends Endocrinol Metab. 2021; 32(12):980-993.

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