Novel and Neuroprotective Tetranortriterpenoids from Chinese Mangrove Xylocarpus Granatum Koenig

Overview

Journal Sci Rep

Specialty Science

Date 2016 Sep 24

PMID 27658619

Citations 6

Authors

Zhen-Fang Zhou

Tibor Kurtan

Attila Mandi

Yu-Cheng Gu

Li-Gong Yao

Guo-Rong Xin

Xu-Wen Li

Yue-Wei Guo

Affiliations

Soon will be listed here.

Abstract

Eight new tetranortriterpenoids (1-8) were isolated from the twigs and leaves of the Chinese mangrove plant Xylocarpus granatum, together with four related known ones (9-12). The structures of new compounds were elucidated by detailed spectroscopic analysis. The absolute configuration of 9-epixylogranatin A (1) was determined by time-dependent density functional theory-electronic circular dichroism (TDDFT-ECD) calculations of the solution conformers. Xylogranatumin A (2) represents the first example of the 9, 10-seco limonoid with an unprecedented oxygen-bridged B ring (2,7-dioxabicyclo[2.2.1]-heptane). All the isolates were evaluated for the in vitro neuroprotective activity, both compounds 11 and 12 displayed moderate effects against HO-induced neurotoxicity in PC12 cells at the concentration of 10 μM, with an increase in cell viability of 12.0% and 11.6%, respectively.

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