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Bioactive Natural Products from Chinese Marine Flora and Fauna

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Specialty Pharmacology
Date 2012 Sep 4
PMID 22941288
Citations 7
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Abstract

In recent decades, the pharmaceutical application potential of marine natural products has attracted much interest from both natural product chemists and pharmacologists. Our group has long been engaged in the search for bioactive natural products from Chinese marine flora (such as mangroves and algae) and fauna (including sponges, soft corals, and mollusks), resulting in the isolation and characterization of numerous novel secondary metabolites spanning a wide range of structural classes and various biosynthetic origins. Of particular interest is the fact that many of these compounds show promising biological activities, including cytotoxic, antibacterial, and enzyme inhibitory effects. By describing representative studies, this review presents a comprehensive summary regarding the achievements and progress made by our group in the past decade. Several interesting examples are discussed in detail.

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References
1.
Yan X, Lin L, Ding J, Guo Y . Methyl spongoate, a cytotoxic steroid from the Sanya soft coral Spongodes sp. Bioorg Med Chem Lett. 2007; 17(9):2661-3. DOI: 10.1016/j.bmcl.2007.01.095. View

2.
Jia R, Guo Y, Chen P, Yang Y, Mollo E, Gavagnin M . Biscembranoids and their probable biogenetic precursor from the Hainan soft coral Sarcophyton tortuosum. J Nat Prod. 2007; 70(7):1158-66. DOI: 10.1021/np060220b. View

3.
Mao S, Guo Y, Shen X . Two novel aromatic valerenane-type sesquiterpenes from the Chinese green alga Caulerpa taxifolia. Bioorg Med Chem Lett. 2006; 16(11):2947-50. DOI: 10.1016/j.bmcl.2006.02.074. View

4.
Chen X, Liu H, Li J, Xin G, Guo Y . Paracaseolide A, first α-alkylbutenolide dimer with an unusual tetraquinane oxa-cage bislactone skeleton from Chinese mangrove Sonneratia paracaseolaris. Org Lett. 2011; 13(19):5032-5. DOI: 10.1021/ol201809q. View

5.
Cai Y, Guo Y, Krohn K . Structure, bioactivities, biosynthetic relationships and chemical synthesis of the spirodioxynaphthalenes. Nat Prod Rep. 2010; 27(12):1840-70. DOI: 10.1039/c0np00031k. View